Reproductive Biology and Endocrinology, 2018 Background Besides being a risk factor for multiple metabolic disorders, obesity could affect female reproduction. While increased adiposity is associated with hormonal changes that could disrupt the function of the hypothalamus and the pituitary ...
Michelle Goldsammler +2 more
doaj +1 more source
The role of agouti-related protein in regulating body weight
Molecular Medicine Today, 1999 Defects in signaling by leptin, a hormone produced primarily by adipose tissue that informs the brain of the body's energy reserves, result in obesity in mice and humans. However, the majority of obese humans do not have abnormalities in leptin or its receptor but instead exhibit leptin resistance that could result from defects in downstream mediators ...
B D, Wilson, M M, Ollmann, G S, Barsh
openaire +2 more sources
Sex differences in basal hypothalamic anorectic and orexigenic gene expression and the effect of quantitative and qualitative food restriction [PDF]
, 2018 Background Research into energy balance and growth has infrequently considered genetic sex, yet there is sexual dimorphism for growth across the animal kingdom.
A Heck +61 more
core +2 more sources
Association between an agouti-related protein gene polymorphism and anorexia nervosa [PDF]
Molecular Psychiatry, 2001 Anorexia nervosa (AN) is a life threatening disorder affecting mostly adolescent women. It is a dramatic psychiatric syndrome accompanied by severe weight loss, hyperactivity and neuroendocrine changes (reviewed in Refs 1 and 2). Several studies have shown a strong genetic component in AN (reviewed in Ref 3).
Vink, T +10 more
openaire +2 more sources
Influence of ghrelin and growth hormone deficiency on AMP-activated protein kinase and hypothalamic lipid metabolism [PDF]
, 2010 This is the peer reviewed version of the article which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving[Abstract] Current ...
Boit, K. Da +7 more
core +2 more sources
Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling* [PDF]
Endocrinology, 1999 Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice ...
B D, Wilson +6 more
openaire +2 more sources
The role of insulin receptor substrate 2 in hypothalamic and beta cell function [PDF]
, 2005 Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H +19 more
core
The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation [PDF]
, 2001 The ability to ensure continuous availability of energy despite highly variable supplies in the environment is a major determinant of the survival of all species.
Björntorp P. +29 more
core +1 more source
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
Gene trap mutation of murine Outer dense fiber protein-2 gene can result in sperm tail abnormalities in mice with high percentage chimaerism [PDF]
, 2010 Background Outer dense fiber protein 2, Odf2, is a major component of the outer dense fibers, ODF, in the flagellum of spermatozoa. ODF are associated with microtubule doublets that form the axoneme.
Heide Tarnasky +5 more
core +1 more source