British Journal of Medicine and Medical Research, 2014 Background: Leptin is an adipocyte derived hormone which is thought to be a key regulator of food intake and body weight. Agouti-related protein also called Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is one of the most potent and long-lasting of appetite stimulators. The appetite stimulating effects
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Hypothalamic regulation of food intake : focus on the anx/anx mouse [PDF]
, 2010 The main goal of this thesis is to increase the knowledge about one of the most important tasks of the brain, the hypothalamic regulation of food intake. The hypothalamus is considered to be the brain s main center for regulation of food intake and it is
Nilsson, Ida
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The effects of graded levels of calorie restriction : VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways [PDF]
, 2016 Acknowledgements We would like to acknowledge the BSU staff for their invaluable help with caring for the animals. Funding The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (BB/G009953/1 and BB/J020028/1) to ...
Chen, Luonan +9 more
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Activation of melanocortin receptors MC1 and MC5 attenuates retinal damage in experimental diabetic retinopathy [PDF]
, 2016 We hypothesize that melanocortin receptors (MC) could activate tissue protective circuit in a model of streptozotocin- (STZ-) induced diabetic retinopathy (DR) in mice.
D'Amico, M. +29 more
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Peptides, 2003 The agouti-related protein (AGRP) is an endogenous antagonist of the brain melanocortin receptors (MC3R and MC4R) and is believed to be involved in feeding behavior and energy homeostasis. Previous results identified that the human AGRP decapeptide Yc[CRFFNAFC]Y binds to the MC3R and MC4R and acts as an antagonist at the MC4R but not at the MC3R.
Department of Medicinal Chemistry, University of Florida, P.O. Box 100485, Gainesville, FL 32610, USA ( host institution ) +6 more
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Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction [PDF]
, 2015 Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission.
Antonio Zorzano, Marc Claret
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The physiological and neuroendocrine correlates of hunger in the Red Junglefowl (Gallus gallus)
Scientific Reports, 2017 The ability to regulate food intake is critical to survival. The hypothalamus is central to this regulation, integrating peripheral signals of energy availability.
J. J. Lees +4 more
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Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models [PDF]
, 2016 The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination and nodal/paranodal domain ...
Bergström, Ulrika
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PLoS ONE, 2013 BackgroundCystine-knot miniproteins, also known as knottins, have shown great potential as molecular scaffolds for the development of targeted therapeutics and diagnostic agents.
Sarah J Moore +3 more
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Hypothalamic mitochondria in energy homeostasis and obesity [PDF]
, 2016 Citation: Guo X, Wu L, Wang W, Medeiros DM, Clarke S, et al.(2016) Hypothalamic mitochondria in energy homeostasis and obesity. Integr Mol Med 3: DOI: 10.15761/IMM.1000209.Obesity, which is largely due to energy imbalance, has emerged as one of the most ...
Chowanadisai, Winyoo +8 more
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