Results 111 to 120 of about 10,922 (223)

Targeting central melanocortin receptors: a promising novel approach for treating alcohol abuse disorders

Frontiers in Neuroscience, 2014
The melanocortin (MC) peptides are produced centrally by propiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus and act through five seven-transmembrane G-protein coupled melanocortin receptor (MCR) subtypes.
Jeffrey eOlney, Montserrat eNavarro, Todd Eric Thiele   +2 more
doaj   +1 more source

Ethanol‐Induced Increase of Agouti‐Related Protein (AgRP) Immunoreactivity in the Arcuate Nucleus of the Hypothalamus of C57BL/6J, but not 129/SvJ, Inbred Mice

Alcoholism: Clinical and Experimental Research, 2010
Background: The melanocortin (MC) system is composed of peptides that are cleaved from the polypeptide precursor, pro‐opiomelanocortin (POMC). Previous research has shown that MC receptor (MCR) agonists reduce, and MCR antagonists increase, ethanol consumption in rats and mice.
Inmaculada, Cubero, Montserrat, Navarro, Francisca, Carvajal, Jose Manuel, Lerma-Cabrera, Todd E, Thiele   +4 more
openaire   +3 more sources

The relationship between Agouti related protein and leptin in patients with methamphetamine use disorder

Middle East Current Psychiatry
Background Appetite regulation involves a complex interplay between peripheral signals and central hypothalamic neuropeptides. Two key hormones in this mechanism are leptin, an adipocyte-derived hormone that suppresses food intake, and Agouti-Related ...
Nehal Mostafa, Wael M. Fathy, Nada El Sayed Selim, Eman Ahmed Abdullah   +3 more
doaj   +1 more source

Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion

BMC Neuroscience, 2010
Background Multiple neuropeptides, sometimes with opposing functions, can be produced from one precursor gene. To study the roles of the different neuropeptides encoded by one large precursor we developed a method to overexpress minigenes and establish ...
de Backer Marijke WA, Brans Maike AD, Luijendijk Mieneke CM, Garner Keith M, van den Heuvel Dianne MA, Pasterkamp R Jeroen, Adan Roger AH   +6 more
doaj   +1 more source

Funktionelle Konsequenzen von Mutationen im Melanocortin-4-Rezeptorgen bei adipösen Kindern und Jugendlichen [PDF]

, 2006
Der Melanocortin-4-Rezeptor spielt eine zentrale Rolle in der Gewichtsregulation, er vermittelt (indirekt) die anorexigenen Effekte des Leptin, indem er nach Aktivierung eine Einstellung der Nahrungsaufnahme und eine Erhöhung der Stoffwechselrate ...
Gudermann, Thomas (Prof. Dr.), Hohmann, Sarah Hortense   +1 more
core   +1 more source

Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] Polymorphisms with Obesity in Northern India

Oman Medical Journal, 2014
Objective: Genetic variants of the melanocortin-4 receptor gene (MC4R), agouti related protein (AGRP) and proopiomelanocortin (POMC) are reported to be associated with obesity.
Apurva Srivastava, Balraj Mittal, Jai Prakash, Varun Shanker Narain, S.M. Natu, Neena Srivastava   +5 more
doaj   +1 more source

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]

, 2013
It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin, Cyr, Nicole E., Litvinov, Bogdan Patedakis, Nillni, Eduardo A., Perello, Mario, Romero, Amparo, Stuart, Ronald C.   +6 more
core   +1 more source

Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

Cell Reports
Summary: Rapid gut-brain communication is critical to maintain energy balance and is disrupted in diet-induced obesity. In particular, the role of carbohydrate overconsumption in the regulation of interoceptive circuits in vivo requires further ...
Carolyn M. Lorch, Nikolas W. Hayes, Jessica L. Xia, Stefan W. Fleps, Hayley E. McMorrow, Haley S. Province, Joshua A. Frydman, Jones G. Parker, Lisa R. Beutler   +8 more
doaj   +1 more source

Coordinated changes in energy intake and expenditure following hypothalamic administration of neuropeptides involved in energy balance

, 2009
OBJECTIVE: The hypothalamic control of energy balance is regulated by a complex network of neuropeptide-releasing neurons. Whilst the effect of these neuropeptides on individual aspects of energy homeostasis has been studied, the coordinated response of ...
AC Linthorst, AD Howard, AJ Dunn, AM Wren, AP Goldstone, AS Chen, C Broberger, C Fekete, C Fekete, C J Small, CB Lawrence, CJ Billington, CK Song, CM Edwards, CR Abbott, CR Abbott, D Huszar, D J L Gunner, D Qu, EC Griffiths, GL de, GS Yeo, J Le Magnen, J Le Magnen, J R C Parkinson, JE Morley, JH Strubbe, JJ Hagan, JM Vaughan, JT Clark, K G Murphy, K Hashimoto, K L Smith, KG Mountjoy, KL Smith, L Negri, M A Ghatei, M Egawa, M Egawa, M Harris, M Monda, M Rossi, M Rossi, M Yokota, MM Ollmann, MM Wirth, MS Kim, MS Kim, N M Semjonous, NJ Spiteri, R Hanada, R Poggioli, S R Bloom, S Schuhler, T Hanada, T Sakurai, Y-L Liu   +56 more
core   +1 more source

Neuroendocrine control of satiation [PDF]

, 2017
Eating is a simple behavior with complex functions. The unconscious neuroendocrine process that stops eating and brings a meal to its end is called satiation. Energy homeostasis is mediated accomplished through the control of meal size via satiation.
Asarian, Lori, Bächler, Thomas
core