Results 91 to 100 of about 10,922 (223)

Transient early food restriction leads to hypothalamic changes in the long‐lived crowded litter female mice [PDF]

, 2015
Transient nutrient restriction in the 3 weeks between birth and weaning (producing “crowded litter” or CL mice) leads to a significant increase in lifespan and is associated with permanent changes in energy homeostasis, leptin, and insulin sensitivity ...
Bartke, Andrzej, Bernal‐mizrachi, Ernesto, Cady, Gillian, Landeryou, Taylor, Miller, Richard A., Sadagurski, Marianna   +5 more
core   +1 more source

Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity

Cell Reports, 2017
Summary: The brain regulates food intake by processing sensory cues and peripheral physiological signals, but the neural basis of this integration remains unclear.
Zhenwei Su, Amber L. Alhadeff, J. Nicholas Betley   +2 more
doaj   +1 more source

The role of accessory proteins and co‐factors in regulation of melanocortin‐4 receptor signalling: An update

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The melanocortin‐4 receptor (MC4R) is a G protein‐coupled receptor with an essential role in appetite suppression and energy homeostasis. Genetic mutations in the receptor and components of its signalling pathway that cause obesity in humans, dogs and rodent models have revealed important insights into how the receptor signals and what ...
Aqfan Jamaluddin, Alyce McClellan, Eleanor Raffan, Caroline M. Gorvin   +3 more
wiley   +1 more source

Cellular and metabolic function of GIRK1 potassium channels expressed by arcuate POMC and NPY/AgRP neurons

Molecules and Cells
: It is well known that the G protein-gated inwardly rectifying K+ (GIRK) channels are critical to maintain excitability of central neurons. GIRK channels consist of 4 subunits and GIRK1/GIRK2 heterotetramers are considered to be the neuronal prototype ...
Yeeun Choi, Eun-Seon Yoo, Youjin Oh, Jong-Woo Sohn   +3 more
doaj   +1 more source

Impact of long‐term maternal high‐fat, high‐sugar feeding on gastric vagal afferent responses and feeding behaviour in mouse offspring

Experimental Physiology, Volume 111, Issue 3, Page 1330-1339, 1 March 2026.
Abstract Poor maternal nutrition and excessive gestational weight gain predict future development of obesity in offspring. Preclinically, maternal obesity induced by a high‐fat, high‐sugar diet (HFHSD) induces hyperphagia and obesity in offspring. We hypothesized that this might, in part, reflect reduced peripheral gastric vagal afferent (GVA) satiety ...
Georgia S. Clarke, Hui Li, Elaheh Heshmati, Kelly M. Gembus, Stephanie E. O'Hara, Lisa M. Nicholas, Kathryn L. Gatford, Amanda J. Page   +7 more
wiley   +1 more source

Neuroendocrine plasticity and crosstalk in pubertal development

Journal of Neuroendocrinology, Volume 38, Issue 2, February 2026.
Abstract Puberty is a critical developmental stage during which individuals acquire the capacity for sexual reproduction. This transition involves a series of complex biological events primarily orchestrated by the activation of the hypothalamo–pituitary–gonadal (HPG) axis.
Carol Fuzeti Elias, Xingfa Han, David Garcia‐Galiano, Cristina Sáenz de Miera   +3 more
wiley   +1 more source

Arcuate nucleus homeostatic systems reflect blood leptin concentration but not feeding behaviour during scheduled feeding on a high-fat diet in mice [PDF]

, 2017
Acknowledgements T.B. was funded by a CASE studentship from the BBSRC and AstraZeneca. J.B. was a summer student from Bordeaux Sciences Agro and funded by student laboratory experience grant from the British Society of Neuroendocrinology. The authors are
Bake, T., Baron, J., Duncan, J. S., Mercer, J. G., Morgan, D. G. A.   +4 more
core   +1 more source

A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make [PDF]

, 2017
Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder with early-onset obesity. Investigation of this entity have increased our insight into the important role of the leptin-melanocortin pathway in energy balance. Here, we present a patient
Achermann, JC, Aycan, Z, Buonocore, F, Cetinkaya, S, Erdeve, SS, Guran, T, Keskin, M, Kurnaz, E, Sagsak, E, Suntharalingham, JP   +9 more
core   +2 more sources

Identification of AgRP cells in the murine hindbrain that drive feeding

Molecular Metabolism
Objective: The central melanocortin system is essential for the regulation of food intake and body weight. Agouti-related protein (AgRP) is the sole orexigenic component of the central melanocortin system and is conserved across mammalian species.
Tomas P. Bachor, Eunsang Hwang, Ernie Yulyaningsih, Kush Attal, Francois Mifsud, Viana Pham, Eirini Vagena, Renzo Huarcaya, Martin Valdearcos, Christian Vaisse, Kevin W. Williams, Paul J. Emmerson, Allison W. Xu   +12 more
doaj   +1 more source

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R. [PDF]

ACS Chem Neurosci, 2021
Ericson MD, Haslach EM, Schnell SM, Freeman KT, Xiang ZM, Portillo FP, Speth R, Litherland SA, Haskell-Luevano C.   +8 more
europepmc   +1 more source