Results 71 to 80 of about 10,922 (223)

Effects of AgRP inhibition on energy balance and metabolism in rodent models. [PDF]

PLoS ONE, 2013
Activation of brain melanocortin-4 receptors (MC4-R) by α-melanocyte-stimulating hormone (MSH) or inhibition by agouti-related protein (AgRP) regulates food intake and energy expenditure and can modulate neuroendocrine responses to changes in energy ...
Roxanne Dutia, Andrea J Kim, Matthew Modes, Robert Rothlein, Jane M Shen, Ye Edward Tian, Jumana Ihbais, Sam F Victory, Carmen Valcarce, Sharon L Wardlaw   +9 more
doaj   +1 more source

Obesity and Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD): A Literature Review on Pathophysiology and Treatment

Diabetes, Obesity and Metabolism, Volume 28, Issue S2, Page 19-30, April 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a key hepatic manifestation of obesity and systemic metabolic dysfunction and is a leading cause of chronic liver disease worldwide. Obesity‐driven mechanisms, including adipose tissue dysfunction, insulin resistance and increased free fatty acid flux to the liver ...
Michael Romanos, Juan M. Garcia Cordova, Jose Villamarin, Juan D. Pazmino Zurita, Andres Acosta   +4 more
wiley   +1 more source

Az ""alacsony T3 szindróma"" kialakulásáért felelős központi idegrendszeri szabályozó mechanizmusok tanulmányozása patkányban = Central regulatory mechanisms involved in the development of the 'low T3 syndrome' [PDF]

, 2008
A pályázat fő célja az éhezés és fertőzés hatására kialakuló centrális hipotiroidizmus kialakulásáért felelős központi idegrendszeri szabályozó mechanizmusok tanulmányozása volt.
Fekete, Csaba, Liposits, Zsolt, Wittmann, Gábor   +2 more
core  

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism [PDF]

, 2015
The absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic signals that regulate food intake and affect
Alzamendi, A., Andreoli, M.F., Castrogiovanni, Daniel, Luque, E., Ramos, R.G., Rossetti, M.F., Stocker, C.   +6 more
core   +1 more source

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

Cell Reports, 2015
Hypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism.
Mark A. Smith, Loukia Katsouri, Elaine E. Irvine, Mohammed K. Hankir, Silvia M.A. Pedroni, Peter J. Voshol, Matthew W. Gordon, Agharul I. Choudhury, Angela Woods, Antonio Vidal-Puig, David Carling, Dominic J. Withers   +11 more
doaj   +1 more source

Chromatin-Binding Protein PHF6 Regulates Activity-Dependent Transcriptional Networks to Promote Hunger Response

Cell Reports, 2020
Summary: Understanding the mechanisms of activity-dependent gene transcription underlying adaptive behaviors is challenging at neuronal-subtype resolution.
Linhua Gan, Jingjing Sun, Shuo Yang, Xiaocui Zhang, Wu Chen, Yiyu Sun, Xiaohua Wu, Cheng Cheng, Jing Yuan, Anan Li, Mark A. Corbett, Mathew P. Dixon, Tim Thomas, Anne K. Voss, Jozef Gécz, Guang-Zhong Wang, Azad Bonni, Qian Li, Ju Huang   +18 more
doaj   +1 more source

Agouti-Related Protein (AGRP) Has a Central Inhibitory Action on the Hypothalamic-Pituitary-Thyroid (HPT) Axis; Comparisons between the Effect of AGRP and Neuropeptide Y on Energy Homeostasis and the HPT Axis [PDF]

Endocrinology, 2002
Because alpha-MSH has a potent stimulatory action on hypophysiotropic TRH synthesizing neurons in the hypothalamic paraventricular nucleus (PVN), preventing the effects of fasting on the gene expression of the TRH prohormone (proTRH), we hypothesized that agouti-related protein (AGRP), a melanocortin receptor antagonist, may exert a central inhibitory ...
Csaba, Fekete, Sumit, Sarkar, William M, Rand, John W, Harney, Charles H, Emerson, Antonio C, Bianco, Ronald M, Lechan   +6 more
openaire   +2 more sources

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Olivier Lavoie, Audrey Turmel, Axelle Khouma, Moein Minbashi Moeini, Chen Liu, Natalie J. Michael, Alexandre Caron   +6 more
wiley   +1 more source

CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]

, 2013
Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core   +1 more source

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

eLife, 2016
Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate structural connections with neurons, their roles in energy homeostasis are less known.
Naiyan Chen, Hiroki Sugihara, Jinah Kim, Zhanyan Fu, Boaz Barak, Mriganka Sur, Guoping Feng, Weiping Han   +7 more
doaj   +1 more source