Results 51 to 60 of about 10,922 (223)

Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes—A Cautionary Tale

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
Two strategies were used to target BMPR1A in adult hypothalamic tanycytes: (1) inducible Rax‐CreERT2 and (2) AAV‐Dio2‐iCre–mediated recombination. Although robust expression of reporter fluorescence and recombination gel analysis confirmed Cre activity in both models, BMPR1A expression was not reduced in targeted tanycytes.
Tianyi Tao, Noelle Leon‐Palmer, Sabrina DiPietro, Kristy L. Townsend   +3 more
wiley   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Intravenous glucagon like peptide-1 infusion does not affect dry matter intake or hypothalamic mRNA expression of neuropeptide Y, agouti related peptide and proopiomelanocortin in wethers [PDF]

, 2014
The objectives of the present study were to determine the effects of jugular vein infusions of glucagon like peptide-1 (GLP-1) and dietary fat inclusion on dry matter intake, nutrient digestibility and hypothalamic mRNA concentration of neuropeptide Y ...
Loerch, S. C., Relling, A. E., Reynolds, Christopher K.   +2 more
core   +1 more source

Effect of eight weeks aerobic exercise on plasma level of agouti-related protein, glycated hemoglobin and glucose in non-active type II diabetic women

مجله دانشگاه علوم پزشکی گرگان, 2015
Background and Objective: Diabetes mellitus is the most common type of metabolic diseases which is characterized with hyperglycemia due to implicit or relative insulin deficiency. Diabetes mellitus is acutely related to obesity.
Ghiasi E, Dabbagh Manesh MH, Daryanoosh F, Nazemzadeghan Gh   +3 more
doaj  

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, Volume 27, Issue 5, May 2026.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source

Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF[alfa]) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose [PDF]

, 2018
K
Deák, Ádám, Hao, Lihong, Potian, Joseph, Rohowsky-Kochan, Christine, Routh, Vanessa H., Sheng, Zhenyu   +5 more
core   +1 more source

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Cell Reports
Summary: Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies of the mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite
Nilufer Sayar-Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Jacob Rysted, Kyle Flippo, Debbie Davis, Iltan Aklan, Bayram Yilmaz, Lin Tian, Deniz Atasoy   +11 more
doaj   +1 more source

Role of hypothalamic melanocortin system in adaptation of food intake to food protein increase in mice. [PDF]

PLoS ONE, 2011
The hypothalamic melanocortin system--the melanocortin receptor of type 4 (MC4R) and its ligands: α-melanin-stimulating hormone (α-MSH, agonist, inducing hypophagia), and agouti-related protein (AgRP, antagonist, inducing hyperphagia)--is considered to ...
Bruno Pillot, Céline Duraffourd, Martine Bégeot, Aurélie Joly, Serge Luquet, Isabelle Houberdon, Danielle Naville, Michèle Vigier, Amandine Gautier-Stein, Christophe Magnan, Gilles Mithieux   +10 more
doaj   +1 more source

Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT The melanocortin‐3 receptor (MC3R) and the melanocortin‐4 receptor (MC4R), both expressed in hypothalamic nuclei, are key downstream effectors of leptin signaling and play important roles in energy homeostasis. While pathogenic variants in the MC4R gene represent the most common cause of monogenic obesity, the clinical significance of MC3R ...
Niels Vos, Alessandro Moro, Wim Van Hul, Lotte Kleinendorst, Ralph J. Florijn, Susanne E. la Fleur, Matthijs Verhage, Mieke M. van Haelst, Ruud F. Toonen   +8 more
wiley   +1 more source

RESTING PLASMA AgRP LEVELS RESPONSE TO EXERCISE-CONJUGATED DIET AND ONLY DIET IN OVERWEIGHT AND OBESE SEDENTARY FEMALES [PDF]

, 2012
Agouti-related peptide (AgRP) is an orexigenic neuropeptide produced mainly in the arcuate nucleus (ARC) of the hypothalamus, which leads to positive energy balance.
Amir Rashidlamir, Firoozeh Delphan, Mahmoud Delphan   +2 more
core