Cell Reports, 2023 Summary: Caloric restriction has anti-inflammatory effects. However, the coordinated physiological actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely unknown.
Michelle L. Klima +7 more
doaj +1 more source
Entwicklung der Adipositas und Neuropeptidexpression bei Melanokortin-4-Rezeptor-defizienten Mäusen unter besonderer Berücksichtigung der Haltungsbedingungen [PDF]
, 2006 Der Melanokortin-4-Rezeptor-Defekt (mit einer Prävalenz von 2-6% in einem adipösen Patientenkollektiv) ist die bisher am häufigsten nachgewiesene monogenetische Form der Adipositas beim Menschen.
Schmidt, Ingrid (Prof. Dr.) +1 more
core +1 more source
Adrenalectomy alters the sensitivity of the central nervous system melanocortin system [PDF]
, 2003 Removal of adrenal steroids by adrenalectomy (ADX) reduces food intake and body weight in rodents and prevents excessive weight gain in many genetic and dietary models of obesity. Thus, glucocorticoids appear to play a key role to promote positive energy
Clegg, DJ +11 more
core +2 more sources
Melanocortin receptor accessory proteins in adrenal disease and obesity. [PDF]
, 2015 Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
Adrian J. Clark +88 more
core +2 more sources
La dieta de alto índice glucémico es un predictor independiente para explicar los cambios en la proteína relacionada al agouti en adolescentes obesos [PDF]
, 2014 The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents.Background & Aims: the role of diet glycemic index (GI) in the control of orexigenic and anorexigenic factors of the energy ...
Campos, Raquel Munhoz da Silveira +9 more
core +2 more sources
Molecular Metabolism, 2023 Objective: The learned associations between sensory cues (e.g., taste, smell) and nutritive value (e.g., calories, post-ingestive signaling) of foods powerfully influences our eating behavior [1], but the neural circuits that mediate these associations ...
Nathaniel T. Nyema +6 more
doaj +1 more source
Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors [PDF]
Bioorganic & Medicinal Chemistry Letters, 2011 A novel hybrid melanocortin pharmacophore was designed based on the topographical similarities between the pharmacophores of Agouti related protein (AGRP) an endogenous melanocortin antagonist, and α-melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin agonist.
Alexander V, Mayorov +8 more
openaire +2 more sources
Influence of ghrelin and growth hormone deficiency on AMP-activated protein kinase and hypothalamic lipid metabolism [PDF]
, 2010 This is the peer reviewed version of the article which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving[Abstract] Current ...
Boit, K. Da +7 more
core +2 more sources
Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit
Frontiers in Neuroscience, 2013 The current obesity epidemic and lack of efficient therapeutics demand a clear understanding of the mechanism underlying body weight regulation. Despite intensive research focus on obesity pathogenesis, an effective therapeutic strategy to treat and cure
Tiemin eLiu +3 more
doaj +1 more source
Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish
Biology, 2023 Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system.
Ana Rocha +3 more
doaj +1 more source