Results 21 to 30 of about 10,922 (223)

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus

Molecular Metabolism, 2017
Objectives: Phytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB1R).
Yury M. Morozov, Marco Koch, Pasko Rakic, Tamas L. Horvath   +3 more
doaj   +1 more source

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike, Cerdá-Reverter, José Miguel, Heyder, Nicolas, Kleinau, Gunnar, Krude, Heiko, Kwiatkowski, Dennis, Kühnen, Peter, Scheerer, Patrick, Soletto, Lucia, Speck, David, Szczepek, Michal   +10 more
core   +1 more source

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction

Cells, 2023
Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza, Pryscila D. S. Teixeira, Niels O. S. Câmara, Jose Donato   +3 more
doaj   +1 more source

Hypothalamic gene expression during voluntary hypophagia in the Sprague-Dawley rat on withdrawal of the palatable liquid diet, Ensure [PDF]

, 2014
Copyright © 2014 Elsevier Inc.
Archer, Zoe A, Duncan, Jacqueline S, Mercer, Julian G   +2 more
core   +1 more source

Effects of hypothalamic neurodegeneration on energy balance. [PDF]

PLoS Biology, 2005
Normal aging in humans and rodents is accompanied by a progressive increase in adiposity. To investigate the role of hypothalamic neuronal circuits in this process, we used a Cre-lox strategy to create mice with specific and progressive degeneration of ...
Allison Wanting Xu, Christopher B Kaelin, Gregory J Morton, Kayoko Ogimoto, Kimber Stanhope, James Graham, Denis G Baskin, Peter Havel, Michael W Schwartz, Gregory S Barsh   +9 more
doaj   +2 more sources

Food intake regulation during pregnancy and lactation in mice with reduced activity of the melanocortin system

Вавиловский журнал генетики и селекции, 2016
Hypothalamic melanortin receptor (MCR) activation inhibits appetite. Neuropeptide Y (NPY) and Agouti Related Protein (AgRP) are coexpressed in some hypothalamic neurons and stimulate feeding, NPY via inhibition of MCR-expressing neurons, and AgRP via ...
E. N. Makarova, I. V. Romanova, N. M. Bazhan   +2 more
doaj   +1 more source

Novel hypophysiotropic AgRP2 neurons and pineal cells revealed by BAC transgenesis in zebrafish [PDF]

, 2017
The neuropeptide agouti-related protein (AgRP) is expressed in the arcuate nucleus of the mammalian hypothalamus and plays a key role in regulating food consumption and energy homeostasis.
Buchshtab, A, Cone, RD, Gothilf, Y, Hawkins, TA, Shainer, I, Wilson, SW   +5 more
core   +1 more source

Sex differences in basal hypothalamic anorectic and orexigenic gene expression and the effect of quantitative and qualitative food restriction [PDF]

, 2018
Background Research into energy balance and growth has infrequently considered genetic sex, yet there is sexual dimorphism for growth across the animal kingdom.
A Heck, AP Arnold, BJ Tolkamp, BK Podisi, BL Nielsen, C Zhang, CJ Savory, D Amadon, D Huszar, D Rigaud, D Zhao, E Decuypere, G Grabauskas, G Maniatis, GB Havenstein, GJ Davies, H Hara, Health EPoA, Welfare, IC De Jong, IC De Jong, IC Dunn, IC Dunn, IC Dunn, J Chue, J Zhang, JA Mench, JJ Lees, JM Brum, JW McRorie Jr, K Ralls, L Lei, L Wang, L Yuan, LG Frank, LK Burke, LM Dixon, M Andersson, M Clinton, M Graham, M Mohammadrezaei, M Perez-Miranda, MJ Fennell, MK Ling, N Goto, N Loganathan, OA Tashani, P Lal, PM Hocking, PM Hocking, R Guillot, R Sears, RJ Agate, T Boswell, T Boswell, T Tachibana, T Tachibana, TM Hahn, V Remes, V Sandilands, V Sandilands, XQ Chen, Z Song   +61 more
core   +2 more sources

Altered features of neurotransmitters: NPY, α-MSH, and AgRP in type 2 diabetic patients with hypertension

Journal of International Medical Research, 2020
Objective To investigate the features of neuropeptide Y (NPY), α-melanocyte stimulating hormone (α-MSH), and agouti-related protein (AgRP) in type 2 diabetes mellitus (T2DM) patients with hypertension.
Baoxin Li, Shuang Ma, Shuqin Guo, Na Li, Dandan Liu, He Wang, Na Zhai, Yunliang Zhang   +7 more
doaj   +1 more source

Arcuate AgRP neurons and the regulation of energy balance

Frontiers in Endocrinology, 2012
The arcuate nucleus of the hypothalamus contains at least two crucial populations of neurons that continuously monitor signals reflecting energy status and promote the appropriate behavioral and metabolic responses to changes in energy demand.
Céline eCansell, Raphaël G.P Denis, Aurélie eJoly-Amado, Julien eCastel, Julien eCastel, Serge H Luquet, Serge H Luquet   +6 more
doaj   +1 more source