Results 11 to 20 of about 10,922 (223)

A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. [PDF]

PLoS ONE, 2013
C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice ...
Mardi S Byerly, Roy Swanson, Zhikui Wei, Marcus M Seldin, Patrick S McCulloh, G William Wong   +5 more
doaj   +5 more sources

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function [PDF]

iScience, 2019
Summary: The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Jihuan Chen, Valerie Chen, Tomoya Kawamura, Ivy Hoang, Yang Yang, Ashley Tess Wong, Ryan McBride, Vez Repunte-Canonigo, Glenn L. Millhauser, Pietro Paolo Sanna   +9 more
doaj   +3 more sources

PGC-1α expression in murine AgRP neurons regulates food intake and energy balance [PDF]

Molecular Metabolism, 2016
Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Jonathan F. Gill, Julien Delezie, Gesa Santos, Christoph Handschin   +3 more
doaj   +5 more sources

Agouti-Related Protein Is Posttranslationally Cleaved by Proprotein Convertase 1 to Generate Agouti-Related Protein (AGRP)83–132: Interaction between AGRP83–132 and Melanocortin Receptors Cannot Be Influenced by Syndecan-3 [PDF]

Endocrinology, 2006
Agouti-related protein (AGRP) plays a key role in energy homeostasis. The carboxyl-terminal domain of AGRP acts as an endogenous antagonist of the melanocortin-4 receptor (MC4-R). It has been suggested that the amino-terminal domain of AGRP binds to syndecan-3, thereby modulating the effects of carboxyl-terminal AGRP at the MC4-R.
Creemers, John W M, Pritchard, Lynn E., Gyte, Amy, Le Rouzic, Philippe, Meulemans, Sandra, Wardlaw, Sharon L., Zhu, Xiaorong, Steiner, Donald F., Davies, Nicola, Armstrong, Duncan, Lawrence, Catherine B., Luckman, Simon M., Schmitz, Catherine A., Davies, Rick A., Brennand, John C., White, Anne   +15 more
openaire   +5 more sources

Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action. It is expressed mainly in the arcuate nucleus where it plays an important role in the hypothalamic control of feeding and energy homeostasis by antagonism of central melanocortin 4 receptors in mammals.
Takeuchi, Sakae, Teshigawara, Kiyoshi, Takahashi, Sumio   +2 more
openaire   +4 more sources

Hypothalamic Cocaine- and Amphetamine-Regulated Transcript (CART) and Agouti-Related Protein (AgRP) Neurons Coexpress the NOP1 Receptor and Nociceptin Alters CART and AgRP Release [PDF]

Endocrinology, 2005
Abstract Nociceptin or orphanin FQ (N/OFQ) and its receptor NOP1 are expressed in hypothalamic nuclei involved in energy homeostasis. N/OFQ administered by intracerebroventricular or arcuate nucleus (ARC) injection increases food intake in satiated rats. The mechanisms by which N/OFQ increases food intake are unknown.
Bewick, GA, Dhillo, WS, Darch, SJ, Murphy, KG, Gardiner, JV, Jethwa, PH, Kong, WM, Ghatei, MA, Bloom, S. R.   +8 more
openaire   +5 more sources

Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity

Peptides, 2003
Agouti-related protein (AGRP) is one of only two known endogenous antagonists of G-protein coupled receptors (GPCRs). Specifically, AGRP antagonizes the brain melanocortin-3 and -4 receptors involved in energy homeostasis, regulation of feeding behavior, and obesity.
Department of Medicinal Chemistry, University of Florida, P.O. Box 100485, Gainesville, FL 32610-0485, USA ( host institution ), Joseph, Christine G. ( author ), Wilczynski, Andrzej ( author ), Holder, Jerry R. ( author ), Xiang, Zhimin ( author ), Bauzo, Rayna M. ( author ), Scott, Joseph W. ( author ), Haskell-Luevano, Carrie ( author )   +7 more
openaire   +5 more sources

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources

Agouti-related protein as the glucose signaling sensor in the central melanocortin circuits in regulating fish food intake

Frontiers in Endocrinology, 2022
Agouti-related protein (AgRP) is a neuropeptide synthesized by AgRP/NPY neurons and transcribed as 132 amino acids in humans and 142 amino acids (AgRP1) in Japanese seabass (Lateolabrax maculatus) fish.
Juan Han, Xiaofang Liang, Yanzhi Guo, Xiaoliang Wu, Ziqi Li, Tiannuo Hong   +5 more
doaj   +1 more source

Agouti Related Protein (AgRP) is Upregulated in Cushing's Syndrome

Experimental and Clinical Endocrinology & Diabetes, 2005
Alpha melanocyte-stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 (MC3-R) and melanocortin 4 (MC4-R) receptors. Alpha-MSH stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing's syndrome have elevated levels of serum alpha-MSH.
Dhillo, WS, Gardiner, JV, Castle, L, Bewick, GA, Smith, KL, Meeran, K, Todd, JF, Ghatei, MA, Bloom, S. R.   +8 more
openaire   +4 more sources