Results 1 to 10 of about 10,922 (223)

Transcriptional Regulation of Agouti-Related Protein (Agrp) in Transgenic Mice [PDF]

Endocrinology, 2004
AbstractAgouti-related protein (Agrp) encodes a hypothalamic neuropeptide that promotes positive energy balance by stimulating food intake and reducing energy expenditure. Agrp expression in the brain is restricted to neurons within the arcuate nucleus of the hypothalamus, and expression levels are elevated as a consequence of food deprivation.
Christopher B, Kaelin, Allison Wanting, Xu, Xin-Yun, Lu, Gregory S, Barsh   +3 more
openaire   +4 more sources

Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Sellers HG, Brown ZL, Khalil NS, Haigh SB, Shivers MA, Patel TV, Joshua AT, Weintraub NL, Barman SA, Belin de Chantemele EJ, Kirov SA, Stepp DW, Fulton DJR.   +12 more
europepmc   +2 more sources

AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice [PDF]

Communications Biology
Hunger enhances the consumption of rewarding foods, but the neurobiological basis of this adaptation remains unclear. We hypothesize that agouti-related protein (AgRP) neurons in the hypothalamic arcuate nucleus (ARH) promote the consumption of rewarding
Daniela A. Cassano, Franco Barrile, Mirta Reynaldo, Gimena Fernandez, María P. Cornejo, María J. Tolosa, María F. Heredia, Nathalia Ferreira, Higor J. Fideles, Pablo N. De Francesco, Helgi B. Schiöth, Rodrigo Rorato, Mario Perelló   +12 more
doaj   +2 more sources

AgRP neurons are not indispensable for body weight maintenance in adult mice

Cell Reports, 2023
Summary: In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in ...
Jing Cai, Jing Chen, Joshua Ortiz-Guzman, Jessica Huang, Benjamin R. Arenkiel, Yuchen Wang, Yan Zhang, Yuyan Shi, Qingchun Tong, Cheng Zhan   +9 more
doaj   +1 more source

AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish

Biomedicines, 2023
Neuronal circuits regulating appetite are dominated by arcuate nucleus neurons, which include appetite-promoting and -suppressing neurons that release the orexigenic neuropeptide agouti-related protein (AgRP) and anorexigenic neuropeptide pro ...
Chiu-Ya Lin, Kun-Yun Yeh, Hsin-Hung Lai, Guor Mour Her   +3 more
doaj   +1 more source

Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity

Cell Reports, 2023
Summary: Resting metabolic rate (RMR) adaptation occurs during obesity and is hypothesized to contribute to failed weight management. Angiotensin II (Ang-II) type 1 (AT1A) receptors in Agouti-related peptide (AgRP) neurons contribute to the integrative ...
Kirthikaa Balapattabi, Yavuz Yavuz, Jingwei Jiang, Guorui Deng, Natalia M. Mathieu, McKenzie L. Ritter, Megan A. Opichka, John J. Reho, John D. McCorvy, Pablo Nakagawa, Lisa L. Morselli, Gary C. Mouradian, Jr., Deniz Atasoy, Huxing Cui, Matthew R. Hodges, Curt D. Sigmund, Justin L. Grobe   +16 more
doaj   +1 more source

Mammalian comparative sequence analysis of the Agrp locus. [PDF]

PLoS ONE, 2007
Agouti-related protein encodes a neuropeptide that stimulates food intake. Agrp expression in the brain is restricted to neurons in the arcuate nucleus of the hypothalamus and is elevated by states of negative energy balance.
Christopher B Kaelin, Gregory M Cooper, Arend Sidow, Gregory S Barsh   +3 more
doaj   +1 more source

GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.

PLoS Biology, 2023
It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated that optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter food ...
Youjin Oh, Eun-Seon Yoo, Sang Hyeon Ju, Eunha Kim, Seulgi Lee, Seyun Kim, Kevin Wickman, Jong-Woo Sohn   +7 more
doaj   +1 more source

Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep

Metabolites, 2021
Agouti-related peptide (AgRP) neurons, which relay information from peripheral metabolic signals, may constitute a key central regulator of reproduction.
Christina M. Merkley, Sydney L. Shuping, Jeffrey R. Sommer, Casey C Nestor   +3 more
doaj   +1 more source

PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. [PDF]

PLoS ONE, 2011
Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1).
Yongheng Cao, Masanori Nakata, Shiki Okamoto, Eisuke Takano, Toshihiko Yada, Yasuhiko Minokoshi, Yukio Hirata, Kazunori Nakajima, Kristy Iskandar, Yoshitake Hayashi, Wataru Ogawa, Gregory S Barsh, Hiroshi Hosoda, Kenji Kangawa, Hiroshi Itoh, Tetsuo Noda, Masato Kasuga, Jun Nakae   +17 more
doaj   +1 more source