Results 1 to 10 of about 17,214 (224)

Atypical Genotypes for Canine Agouti Signaling Protein Suggest Novel Chromosomal Rearrangement. [PDF]

Genes (Basel), 2020
Canine coat color is a readily observed phenotype of great interest to dog enthusiasts; it is also an excellent avenue to explore the mechanisms of genetics and inheritance. As such, multiple commercial testing laboratories include basic color alleles in their popular screening panels, allowing for the creation of genotyped datasets at a scale not ...
Dreger DL, Anderson H, Donner J, Clark JA, Dykstra A, Hughes AM, Ekenstedt KJ.   +6 more
europepmc   +4 more sources

Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle [PDF]

Frontiers in Physiology, 2018
Transcriptome analyses of bovine muscle tissue differing in intramuscular fat (IMF) content identified agouti signaling protein (ASIP) as a promising candidate gene for fat deposition.
Yinuo Liu, Yinuo Liu, Elke Albrecht, Lisa Schering, Christa Kuehn, Runjun Yang, Zhihui Zhao, Steffen Maak   +7 more
doaj   +2 more sources

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. [PDF]

Nat Metab, 2022
Abstract Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The mutation places
Kempf E, Landgraf K, Stein R, Hanschkow M, Hilbert A, Abou Jamra R, Boczki P, Herberth G, Kühnapfel A, Tseng YH, Stäubert C, Schöneberg T, Kühnen P, Rayner NW, Zeggini E, Kiess W, Blüher M, Körner A.   +17 more
europepmc   +5 more sources

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]

Frontiers in Endocrinology, 2019
The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Nicolas Heyder, Gunnar Kleinau, Michal Szczepek, Dennis Kwiatkowski, David Speck, Lucia Soletto, José Miguel Cerdá-Reverter, Heiko Krude, Peter Kühnen, Heike Biebermann, Patrick Scheerer   +10 more
doaj   +3 more sources

Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study [PDF]

Pharmaceuticals
Background: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Farah Maarfi, Mohammed Cherkaoui, Sana Afreen, Mohd Yasir Khan   +3 more
doaj   +2 more sources

Local Agouti Signaling Protein/Melanocortin Signaling System that Possibly Regulates Lipid Metabolism in Adipose Tissues of Chickens

The Journal of Poultry Science, 2010
The agouti signaling protein (ASIP)/melanocortin signaling system regulates lipid metabolism in humans but not in mice. To examine whether the system is present in adipose tissues in chickens, we performed reverse transcription-polymerase chain reaction
Masafumi Yabuuchi, Kana Bando, Misato Hiramatsu, Sumio Takahashi, Sakae Takeuchi   +4 more
doaj   +3 more sources

Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Sellers HG, Brown ZL, Khalil NS, Haigh SB, Shivers MA, Patel TV, Joshua AT, Weintraub NL, Barman SA, Belin de Chantemele EJ, Kirov SA, Stepp DW, Fulton DJR.   +12 more
europepmc   +2 more sources

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging [PDF]

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
doaj   +2 more sources

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) Neurons. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Minbashi Moeini M, Lavoie O, Caron A, Williams KW, Michael NJ.   +4 more
europepmc   +2 more sources

Integration of Nutrient Sensing in Fish Hypothalamus

Frontiers in Neuroscience, 2021
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid ...
José L. Soengas
doaj   +1 more source