Alteration of sheep coat color pattern by disruption of ASIP gene via CRISPR Cas9
Coat color is an important characteristic and economic trait in domestic sheep. Aiming at alteration of Chinese merino sheep coat color by genome manipulation, we disrupted sheep agouti signaling protein gene by CRISPR/Cas9.
Xuemei Zhang +14 more
doaj +1 more source
Pathophysiology of melanocortin receptors and their accessory proteins. [PDF]
The melanocortin receptors (MCRs) and their accessory proteins (MRAPs) are involved in regulation of a diverse range of endocrine pathways. Genetic variants of these components result in phenotypic variation and disease. The MC1R is expressed in skin and
A.J.L. Clark +126 more
core +2 more sources
Molecular studies of hypothalamic food intake regulating systems and central myelination in two anorectic mouse models [PDF]
The aim of this thesis is to increase the understanding of the hypothalamic mechanisms that are vital for food intake regulation, in particular as it relates to anorexia, and the molecular mechanisms underlying myelination and nodal/paranodal domain ...
Bergström, Ulrika
core +1 more source
Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad
Psychosocial stress alters several physiological parameters resulting in multiple disorders, particularly compromising the immune system thereby provoking various diseases including liver disorders.
Syeda Momna Ishtiaq +2 more
doaj +1 more source
The role of insulin receptor substrate 2 in hypothalamic and beta cell function [PDF]
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H +19 more
core
Roe deer meat is a prized game product in many European countries. However, concerns exist regarding the accuracy of the amount of declared roe deer in processed game meat foods.
Bukola M. Adenuga +6 more
doaj +1 more source
An Agouti-Signaling-Protein Mutation is Strongly Associated with Melanism in European Roe Deer (Capreolus capreolus). [PDF]
Reissmann M +4 more
europepmc +1 more source
The association between neuropeptide levels, lifestyle and BMI in postpartum women – a follow-up study [PDF]
“The association between neuropeptide levels, lifestyle and BMI in postpartum women – a follow-up study” Author: Ameli Ingemansson. Supervisor: Ulrika Andersson Hall.
Ingemansson, Ameli
core
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
Immune cell differentiation and function are crucially dependent on specific metabolic programs dictated by mitochondria, including the generation of ATP from the oxidation of nutrients and supplying precursors for the synthesis of macromolecules and ...
Pearce, E., Rambold, A.
core +1 more source

