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Loop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and Antagonism [PDF]
Journal of Molecular Biology, 2010 Agouti-related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play critical roles in energy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate melanocortin receptors. Signaling specificity is mediated in part through receptor binding selectivity brought about by alterations in the ...
Greg Barsh +2 more
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Journal of Mammalian Evolution, 2010
Agouti is a common pigmentation phenotype in mammals including primates. Mutations in the agouti signaling protein gene (ASIP) are known to result in non-agouti black hairs in laboratory mice. It is still unclear whether sequence variation in ASIP is linked with the agouti/non-agouti phenotypes in macaques (Genus Macaca). To address this issue, we have
Takafumi Ishida +2 more
exaly +2 more sources
Agouti is a common pigmentation phenotype in mammals including primates. Mutations in the agouti signaling protein gene (ASIP) are known to result in non-agouti black hairs in laboratory mice. It is still unclear whether sequence variation in ASIP is linked with the agouti/non-agouti phenotypes in macaques (Genus Macaca). To address this issue, we have
Takafumi Ishida +2 more
exaly +2 more sources
Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts [PDF]
Developmental Dynamics, 2001 AbstractThe melanocyte lineage potentially forms an attractive model system for studies in cell differentiation, developmental genetics, cell signaling, and melanoma, because differentiated cells produce the visible pigment melanin. Immortal lines of murine melanoblasts (melanocyte precursors) have been described previously, but induction of ...
Greg Barsh, Dorothy C Bennett
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Cells & Development, 2023
The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, or oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy following fertilization.
Heather L, Chaney +5 more
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The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, or oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy following fertilization.
Heather L, Chaney +5 more
openaire +2 more sources
Bioactive Motifs of Agouti Signal Protein
Experimental Cell Research, 2000The switch between the synthesis of eu- and pheomelanins is modulated by the interaction of two paracrine signaling molecules, alpha-melanocyte stimulating hormone (MSH) and agouti signal protein (ASP), which interact with melanocytes via the MSH receptor (MC1R).
V M, Virador +4 more
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Agouti‐Related Proteins (AGRPs) and Agouti‐Signaling Peptide (ASIP) in Fish and Chicken
Annals of the New York Academy of Sciences, 2005Abstract: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two ...
Janis, Klovins, Helgi B, Schiöth
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American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2001
Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti radioligand.
Ying-Kui Yang +2 more
exaly +3 more sources
Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti radioligand.
Ying-Kui Yang +2 more
exaly +3 more sources
Agouti Signal Protein Regulation in Human Melanoma Cells
Pigment Cell Research, 2003Production of the pigment eumelanin is controlled by α‐melanocyte stimulating hormone (α‐MSH) stimulation of melanocortin 1 receptor (Mc1r), whereas production of pheomelanin results from agouti antagonism of α‐MSH signalling through Mc1r. The role of agouti in mouse pigmentation has been extensively investigated but a role for agouti signalling ...
Voisey, Joanne +2 more
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Expression and function of agouti signaling protein in cattle
Animal Science Journal, 2006ABSTRACTAgouti signaling protein (ASIP) is involved in the regulation of pigmentation in mammals by downregulating melanocortin 1 receptor (MC1R) activity. In wild type mice, ASIP is expressed in skin and testes. Widespread tissue expression of ASIP has been found in humans and cattle.
Daria GRAPHODATSKAYA +4 more
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Expression of Agouti Signaling Protein gene (ASIP) in Pigs
Nihon Chikusan Gakkaiho, 2005 OKUMURA, Naohiko +2 more
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