Results 141 to 150 of about 9,208 (167)

Agouti Signaling Protein Stimulates Islet Amyloid Polypeptide (Amylin) Secretion in Pancreatic β-Cells

Experimental Biology and Medicine, 2001
Ectopic overexpression of the murine agouti gene results in yellow coat color, obesity, hyperinsulinemia, and type II diabetes. We have shown the human homologue of agouti (agouti signaling protein; ASP) to regulate human adipocyte metabolism and lipid storage via a Ca 2+ -dependent mechanism.
Bingzhong Xue, Michael Zemel
exaly   +3 more sources

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A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA

Pigment Cell Research, 2006
SummaryTo date, a role for agouti signalling protein (ASIP) in human pigmentation has not been well characterized. It is known that agouti plays a pivotal role in the pigment switch from the dark eumelanin to the light pheomelanin in the mouse. However, because humans do not have an agouti banded hair pattern, its role in human pigmentation has been ...
Voisey, J, del C. Gomez-Cabrera, Maria, Smit, D J, Leonard, J H, Sturm, R A, van Daal, Angela   +5 more
openaire   +5 more sources

Growth Performance After Agouti-Signaling Protein 1 ( Asip1 ) Overexpression in Transgenic Zebrafish

Zebrafish, 2020
The melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. ASIP regulates dorsal-ventral pigment polarity through melanocortin 1 receptor (MC1R) and overexpression ...
Godino-Gimeno, Alejandra, Sánchez, Elisa, Guillot, Raúl, Rocha, Ana, Angotzi, Anna Rita, Leal, Esther, Rotllant, Josep, Cerdá-Reverter, José Miguel   +7 more
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Population Differences in the Frequency of the Agouti Signaling Protein g.8818A>G Polymorphism

Pigment Cell Research, 2004
The role of agouti signaling protein (ASIP) in human pigmentation pathways is not definitively understood although its murine homologue regulates, in part, pheomelanogenesis. We have reported an association of a polymorphism in the 3′‐untranslated region of ASIP (g.8818A>G) with dark hair and eye color among a group of European‐Americans (Am J Hum ...
Charnita, Zeigler-Johnson, Saarene, Panossian, Serigne M, Gueye, Mohamed, Jalloh, David, Ofori-Adjei, Peter A, Kanetsky   +5 more
openaire   +2 more sources

N-terminal domains and site-specific glycosylation regulate the secretion of avian melanocortin inverse agonists, agouti signaling protein (ASIP) and agouti-related protein (AGRP)

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Agouti signaling protein (ASIP) and agouti-related protein (AGRP) are paralogous inverse agonists of melanocortin receptors with distinct physiological roles, but their structural and biochemical properties in birds remain poorly understood. Here, we characterized chicken ASIP and AGRP proteins.
Sayaka Aizawa, Sakae Takeuchi, Tatsuhiko Abo   +2 more
exaly   +4 more sources

Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein

General and Comparative Endocrinology, 2012
Hair and feather pigmentation is mainly determined by the distribution of two kinds of melanin, eumelanin and pheomelanin, which produce brown to black and yellow to red colorations, respectively. The agouti signaling protein (ASIP) acts as an antagonist or an inverse agonist of the melanocortin 1 receptor (MC1R), a G protein-coupled receptor for α ...
Chihiro, Yoshihara, Ayaka, Fukao, Keita, Ando, Yuichi, Tashiro, Shusuke, Taniuchi, Sumio, Takahashi, Sakae, Takeuchi   +6 more
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The Interaction of Agouti Signal Protein and Melanocyte Stimulating Hormone to Regulate Melanin Formation in Mammals

Pigment Cell Research, 1996
Important regulatory controls of melanogenesis that operate at the subcellular level to modulate the structural and/or the functional nature of the melanins and melanin granules produced in melanocytes are reviewed. Melanocyte stimulating hormone and agouti signal protein have antagonistic roles and possibly opposing mechanisms of action in the ...
M, Furumura, C, Sakai, Z, Abdel-Malek, G S, Barsh, V J, Hearing   +4 more
openaire   +2 more sources

Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates

Mammalian Genome, 2006
We investigated variation in the gene encoding the agouti signaling protein (ASIP) in relation to coat color evolution in primates. We found little evidence that mutations in the coding region of ASIP have been involved in color changes among closely related primate species.
Nicholas I, Mundy, Joanne, Kelly
openaire   +2 more sources

In Situ Localization of Agouti Signal Protein in Murine Skin Using Immunohistochemistry with an ASP-Specific Antibody

Biochemical and Biophysical Research Communications, 2000
Switching between production of eumelanin or pheomelanin in follicular melanocytes is responsible for hair color in mammals; in mice, this switch is controlled by the agouti locus, which encodes agouti signal protein (ASP) through the action of melanocortin receptor 1. To study expression and processing patterns of ASP in the skin and its regulation of
N, Matsunaga, V, Virador, C, Santis, W D, Vieira, M, Furumura, J, Matsunaga, N, Kobayashi, V J, Hearing   +7 more
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Conserved distal promoter of the agouti signaling protein (ASIP) gene controls sexual dichromatism in chickens

General and Comparative Endocrinology, 2012
Brilliant plumage is typical of male birds, thus sexual plumage dichromatism is seen in many avian species; however, the molecular mechanism underlying this remains unclear. The agouti signaling protein (ASIP) is a paracrine factor that stimulates yellow/red pigment (pheomelanin) synthesis and inhibits black/brown pigment (eumelanin) synthesis in ...
Eri, Oribe, Ayaka, Fukao, Chihiro, Yoshihara, Misa, Mendori, Karen G, Rosal, Sumio, Takahashi, Sakae, Takeuchi   +6 more
openaire   +2 more sources