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N-terminal domains and site-specific glycosylation regulate the secretion of avian melanocortin inverse agonists, agouti signaling protein (ASIP) and agouti-related protein (AGRP)

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Agouti signaling protein (ASIP) and agouti-related protein (AGRP) are paralogous inverse agonists of melanocortin receptors with distinct physiological roles, but their structural and biochemical properties in birds remain poorly understood.
Tatsuhiko Abo, Sayaka Aizawa, Sakae Takeuchi   +2 more
exaly   +6 more sources

Growth Performance After Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish

Zebrafish, 2020
The melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight.
Alejandra Godino-Gimeno, E. Sánchez, R. Guillot, Ana Rocha, A. R. Angotzi, E. Leal, J. Rotllant, J. M. Cerdá-Reverter   +7 more
semanticscholar   +7 more sources

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Characterization of agouti-signaling protein (ASIP) in the bovine ovary and throughout early embryogenesis

Cells and Development, 2023
The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, or oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy following ...
Mingxiang Zhang, Jianbo Yao
exaly   +4 more sources

Potential Causative Mutation for Melanism in Rats Identified in the Agouti Signaling Protein Gene (Asip) of the Rattus rattus Species Complex on Okinawa Island, Japan

Zoological Science, 2017
The occurrence of black fur, or melanism, in many mammalian species is known to be linked to DNA sequence variation in the agouti signaling protein (Asip) gene, which is a major determinant of eumelanin and pheomelanin pigments in coat color.
Vicki A Thomson, Hitoshi Suzuki
exaly   +3 more sources

Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein [PDF]

FEBS Letters, 2007
The agouti signaling protein (ASIP) and its homolog, the agouti‐related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals. NMR investigations find that the C‐terminal domains of these proteins adopt a fold consistent with an inhibitor cystine knot (ICK), previously identified in ...
Glenn L Millhauser
exaly   +4 more sources

Structures of the Agouti Signaling Protein

Journal of Molecular Biology, 2005
Expression of the agouti signaling protein (ASIP) during hair growth produces the red/yellow pigment pheomelanin. ASIP, and its neuropeptide homolog the agouti-related protein (AgRP) involved in energy balance, are novel, paracrine signaling molecules that act as inverse agonists at distinct subsets of melanocortin receptors. Ubiquitous ASIP expression
Darren A Thompson, Biaoxin Chai, Ira Gantz   +2 more
exaly   +4 more sources

Functional properties of an agouti signaling protein variant and characteristics of its cognate radioligand

American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2001
Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti radioligand.
Ying-Kui Yang, Chris Dickinson, Ji-Yao Li   +2 more
exaly   +4 more sources

Agouti Signaling Protein Stimulates Islet Amyloid Polypeptide (Amylin) Secretion in Pancreatic β-Cells

Experimental Biology and Medicine, 2001
Ectopic overexpression of the murine agouti gene results in yellow coat color, obesity, hyperinsulinemia, and type II diabetes. We have shown the human homologue of agouti (agouti signaling protein; ASP) to regulate human adipocyte metabolism and lipid storage via a Ca 2+ -dependent mechanism.
Bingzhong Xue, Michael B Zemel
exaly   +4 more sources

Left-right pigmentation pattern of Japanese flounder corresponds to expression levels of melanocortin receptors (MC1R and MC5R), but not to agouti signaling protein 1 (ASIP1) expression

General and Comparative Endocrinology, 2018
Body coloration in flatfish is one of the most distinctive asymmetries in the animal kingdom, although the fundamental molecular mechanism of the pigmentation is unclear.
Satoshi Kasagi, Reiji Masuda, Akiyoshi Takahashi   +2 more
exaly   +2 more sources

Expression and function of agouti signaling protein in cattle

Animal Science Journal, 2006
ABSTRACTAgouti signaling protein (ASIP) is involved in the regulation of pigmentation in mammals by downregulating melanocortin 1 receptor (MC1R) activity. In wild type mice, ASIP is expressed in skin and testes. Widespread tissue expression of ASIP has been found in humans and cattle.
Fredi Janett
exaly   +2 more sources