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A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA
Pigment Cell Research, 2006SummaryTo date, a role for agouti signalling protein (ASIP) in human pigmentation has not been well characterized. It is known that agouti plays a pivotal role in the pigment switch from the dark eumelanin to the light pheomelanin in the mouse. However, because humans do not have an agouti banded hair pattern, its role in human pigmentation has been ...
Voisey, J +5 more
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Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores [PDF]
Journal of Biological Chemistry, 1999 Agouti protein and Agouti-related protein (Agrp) regulate pigmentation and body weight, respectively, by antagonizing melanocortin receptor signaling. A carboxyl-terminal fragment of Agouti protein, Ser73-Cys131, is sufficient for melanocortin receptor antagonism, but Western blot analysis of skin extracts reveals that the electrophoretic mobility of ...
Michael M Ollmann, Gregory S Barsh
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84 Characterization of agouti-signalling protein expression within the bovine ovary and early embryo
Reproduction, Fertility and Development, 2021Factors present in the oocyte and surrounding follicular cells aid in the attainment of oocyte competence. Agouti-signalling protein (ASIP) is a known regulator of melanocyte function through binding to melanocortin receptors including MC1R and MC4R.
H. Baldwin, M. Zhang, J. Current, J. Yao
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Population Differences in the Frequency of the Agouti Signaling Protein g.8818A>G Polymorphism
Pigment Cell Research, 2004The role of agouti signaling protein (ASIP) in human pigmentation pathways is not definitively understood although its murine homologue regulates, in part, pheomelanogenesis. We have reported an association of a polymorphism in the 3′‐untranslated region of ASIP (g.8818A>G) with dark hair and eye color among a group of European‐Americans (Am J Hum ...
Charnita, Zeigler-Johnson +5 more
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Pigment Cell Research, 1996
Important regulatory controls of melanogenesis that operate at the subcellular level to modulate the structural and/or the functional nature of the melanins and melanin granules produced in melanocytes are reviewed. Melanocyte stimulating hormone and agouti signal protein have antagonistic roles and possibly opposing mechanisms of action in the ...
M, Furumura +4 more
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Important regulatory controls of melanogenesis that operate at the subcellular level to modulate the structural and/or the functional nature of the melanins and melanin granules produced in melanocytes are reviewed. Melanocyte stimulating hormone and agouti signal protein have antagonistic roles and possibly opposing mechanisms of action in the ...
M, Furumura +4 more
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Mammalian Genome, 2006
We investigated variation in the gene encoding the agouti signaling protein (ASIP) in relation to coat color evolution in primates. We found little evidence that mutations in the coding region of ASIP have been involved in color changes among closely related primate species.
Nicholas I, Mundy, Joanne, Kelly
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We investigated variation in the gene encoding the agouti signaling protein (ASIP) in relation to coat color evolution in primates. We found little evidence that mutations in the coding region of ASIP have been involved in color changes among closely related primate species.
Nicholas I, Mundy, Joanne, Kelly
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Biochemical and Biophysical Research Communications, 2000
Switching between production of eumelanin or pheomelanin in follicular melanocytes is responsible for hair color in mammals; in mice, this switch is controlled by the agouti locus, which encodes agouti signal protein (ASP) through the action of melanocortin receptor 1. To study expression and processing patterns of ASP in the skin and its regulation of
N, Matsunaga +7 more
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Switching between production of eumelanin or pheomelanin in follicular melanocytes is responsible for hair color in mammals; in mice, this switch is controlled by the agouti locus, which encodes agouti signal protein (ASP) through the action of melanocortin receptor 1. To study expression and processing patterns of ASP in the skin and its regulation of
N, Matsunaga +7 more
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109 Agouti-signalling protein impacts blastocyst development in cattle
Reproduction, Fertility and Development, 2022H. Chaney, J. Current, J. Yao
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