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Navigating the Strengths and Constraints of Mouse Models in Obesity Research.
EndocrinologyDelhanty PJD, Visser JA.
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Structures of the Agouti Signaling Protein
Journal of Molecular Biology, 2005Expression of the agouti signaling protein (ASIP) during hair growth produces the red/yellow pigment pheomelanin. ASIP, and its neuropeptide homolog the agouti-related protein (AgRP) involved in energy balance, are novel, paracrine signaling molecules that act as inverse agonists at distinct subsets of melanocortin receptors. Ubiquitous ASIP expression
Joseph C, McNulty +7 more
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Expression and function of agouti signaling protein in cattle
Animal Science Journal, 2006ABSTRACTAgouti signaling protein (ASIP) is involved in the regulation of pigmentation in mammals by downregulating melanocortin 1 receptor (MC1R) activity. In wild type mice, ASIP is expressed in skin and testes. Widespread tissue expression of ASIP has been found in humans and cattle.
Daria GRAPHODATSKAYA +4 more
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2001
Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti radioligand.
Y K, Yang +4 more
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Agouti signaling protein (ASIP), the human (h) homolog of agouti, is an endogenous melanocortin peptide antagonist. To date, characterization of this protein has been performed with recombinant protein only and without the availability of an ASIP/agouti radioligand.
Y K, Yang +4 more
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Bioactive Motifs of Agouti Signal Protein
Experimental Cell Research, 2000The switch between the synthesis of eu- and pheomelanins is modulated by the interaction of two paracrine signaling molecules, alpha-melanocyte stimulating hormone (MSH) and agouti signal protein (ASP), which interact with melanocytes via the MSH receptor (MC1R).
V M, Virador +4 more
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Agouti Signal Protein Regulation in Human Melanoma Cells
Pigment Cell Research, 2003Production of the pigment eumelanin is controlled by α‐melanocyte stimulating hormone (α‐MSH) stimulation of melanocortin 1 receptor (Mc1r), whereas production of pheomelanin results from agouti antagonism of α‐MSH signalling through Mc1r. The role of agouti in mouse pigmentation has been extensively investigated but a role for agouti signalling ...
Voisey, Joanne +2 more
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Agouti‐Related Proteins (AGRPs) and Agouti‐Signaling Peptide (ASIP) in Fish and Chicken
Annals of the New York Academy of Sciences, 2005Abstract: We performed an intensive search on sequence databases to identify orthologues of ASIP and AGRP peptides in a number of different species, revealing a number of genomic fragments coding for the C‐terminal part of agouti‐related motifs, different from annotated peptide sequences, including one fragment from chicken, two from zebrafish, two ...
Janis, Klovins, Helgi B, Schiöth
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Cells & Development, 2023
The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, or oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy following fertilization.
Heather L, Chaney +5 more
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The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, or oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy following fertilization.
Heather L, Chaney +5 more
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Journal of Mammalian Evolution, 2010
Agouti is a common pigmentation phenotype in mammals including primates. Mutations in the agouti signaling protein gene (ASIP) are known to result in non-agouti black hairs in laboratory mice. It is still unclear whether sequence variation in ASIP is linked with the agouti/non-agouti phenotypes in macaques (Genus Macaca). To address this issue, we have
Kazuhiro Nakayama +3 more
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Agouti is a common pigmentation phenotype in mammals including primates. Mutations in the agouti signaling protein gene (ASIP) are known to result in non-agouti black hairs in laboratory mice. It is still unclear whether sequence variation in ASIP is linked with the agouti/non-agouti phenotypes in macaques (Genus Macaca). To address this issue, we have
Kazuhiro Nakayama +3 more
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84 Characterization of agouti-signalling protein expression within the bovine ovary and early embryo
Reproduction, Fertility and Development, 2021Factors present in the oocyte and surrounding follicular cells aid in the attainment of oocyte competence. Agouti-signalling protein (ASIP) is a known regulator of melanocyte function through binding to melanocortin receptors including MC1R and MC4R.
H. Baldwin, M. Zhang, J. Current, J. Yao
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