Results 11 to 20 of about 17,214 (224)
Effects of Recombinant Agouti-Signaling Protein on Melanocortin Action [PDF]
Molecular Endocrinology, 1997 Mouse agouti protein is a paracrine signaling molecule that has previously been demonstrated to be an antagonist of melanocortin action at several cloned rodent and human melanocortin receptors. In this study we report the effects of agouti-signaling protein (ASIP), the human homolog of mouse agouti, on the action of alpha-MSH or ACTH at the five known
Y K, Yang +6 more
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Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish
Animals, 2022 In teleost, as in other vertebrates, stress affects reproduction. A key component of the stress response is the pituitary secretion of the adrenocorticotropic hormone (ACTH), which binds to the melanocortin 2 receptor (MC2R) in the adrenal glands and ...
Sandra Navarro +6 more
doaj +1 more source
Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish
Biology, 2023 Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system. Overexpression of the inverse agonist agouti-signalling protein (ASIP) and agouti-related protein (AGRP) leads to enhanced food intake, linear growth, and weight. In zebrafish, overexpression of
Ana Rocha +3 more
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Frontiers in Endocrinology, 2022 Agouti-related protein (AgRP) is a neuropeptide synthesized by AgRP/NPY neurons and transcribed as 132 amino acids in humans and 142 amino acids (AgRP1) in Japanese seabass (Lateolabrax maculatus) fish.
Juan Han +5 more
doaj +1 more source
The Journal of Poultry Science, 2022 Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism.
Takaoki Saneyasu +5 more
doaj +1 more source
Melanism in peromyscus is caused by independent mutations in agouti. [PDF]
PLoS ONE, 2009 Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence the maintenance of phenotypic diversity.
Evan P Kingsley +3 more
doaj +1 more source
Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling* [PDF]
Endocrinology, 1999 Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice ...
B D, Wilson +6 more
openaire +3 more sources
Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
core +3 more sources
Modulation of murine melanocyte function invitro by agouti signal protein [PDF]
The EMBO Journal, 1997 Molecular and biochemical mechanisms that switch melanocytes between the production of eumelanin or pheomelanin involve the opposing action of two intercellular signaling molecules, alpha-melanocyte-stimulating hormone (MSH) and agouti signal protein (ASP).
C, Sakai +8 more
openaire +2 more sources
A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. [PDF]
, 2013 C1q/TNF-related protein 13 (CTRP13), a hormone secreted by adipose tissue (adipokines), helps regulate glucose metabolism in peripheral tissues. We previously reported that CTRP13 expression is increased in obese and hyperphagic leptin-deficient mice ...
Byerly, Mardi S +5 more
core +6 more sources