Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed. [PDF]
, 2014 Coat colours and patterns are highly variable in cats and are determined mainly by several genes with Mendelian inheritance. A 2-bp deletion in agouti signalling protein (ASIP) is associated with melanism in domestic cats. Bengal cats are hybrids between
Davis, BW +5 more
core +1 more source
Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue [PDF]
, 2011 Background: Normal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (paired-like homeodomain transcription factor 2, isoform c), a key regulator of left-right asymmetry, has recently ...
Brown, NA +8 more
core +3 more sources
The differential expression of MC1R regulators in dorsal and ventral quail plumages during embryogenesis: Implications for plumage pattern formation. [PDF]
PLoS ONE, 2017 Melanin pigmentation patterns are ubiquitous in animals and function in crypsis, physical protection, thermoregulation and signalling. In vertebrates, pigmentation patterns formed over large body regions as well as within appendages (hair/feathers) may ...
Thanh-Lan Gluckman, Nicholas I Mundy
doaj +1 more source
Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]
, 2014 Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari +5 more
core +2 more sources
Growth Performance After Agouti-Signaling Protein 1 (Asip1) Overexpression in Transgenic Zebrafish
Zebrafish, 2020 The melanocortin system is a key structure in the regulation of energy balance. Overexpression of inverse agonists, agouti-signaling protein (ASIP), and agouti-related protein (AGRP) results in increased food intake, linear growth, and body weight. ASIP regulates dorsal-ventral pigment polarity through melanocortin 1 receptor (MC1R) and overexpression ...
Godino-Gimeno, Alejandra +7 more
openaire +4 more sources
Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts [PDF]
Developmental Dynamics, 2001 AbstractThe melanocyte lineage potentially forms an attractive model system for studies in cell differentiation, developmental genetics, cell signaling, and melanoma, because differentiated cells produce the visible pigment melanin. Immortal lines of murine melanoblasts (melanocyte precursors) have been described previously, but induction of ...
E V, Sviderskaya +4 more
openaire +2 more sources
Cell Reports, 2023 Summary: Caloric restriction has anti-inflammatory effects. However, the coordinated physiological actions that lead to reduced inflammation in a state of caloric deficit (hunger) are largely unknown.
Michelle L. Klima +7 more
doaj +1 more source
A Polymorphism in the Agouti Signaling Protein Gene Is Associated with Human Pigmentation [PDF]
The American Journal of Human Genetics, 2002 In mice and humans, binding of alpha-melanocyte--stimulating hormone to the melanocyte-stimulating--hormone receptor (MSHR), the protein product of melanocortin-1 receptor (MC1R) gene, leads to the synthesis of eumelanin. In the mouse, ligation of MSHR by agouti signaling protein (ASP) results in the production of pheomelanin. The role of ASP in humans
Kanetsky, Peter A. +5 more
openaire +2 more sources
Cell Reports, 2015 Hypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism.
Mark A. Smith +11 more
doaj +1 more source
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017 The basic colour in horses, such as black, brown and chestnut is affected by only two genes MC1R and ASIP. Other colours in horses are affected by modifying genes, such as dilution gene MATP.
Eliška Horecká +2 more
doaj +1 more source