Hypothalamic GHR—SIRT1 Axis in Fasting
Cells, 2021 Many aspects of physiological functions are controlled by the hypothalamus, a brain region that connects the neuroendocrine system to whole-body metabolism.
Juliana Bezerra Medeiros de Lima +5 more
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Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. [PDF]
, 2019 There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these
Atkinson, Mark A +6 more
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Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein [PDF]
FEBS Letters, 2007 The agouti signaling protein (ASIP) and its homolog, the agouti‐related protein (AgRP), act as inverse agonists that control, respectively, pigmentation and metabolic function in mammals. NMR investigations find that the C‐terminal domains of these proteins adopt a fold consistent with an inhibitor cystine knot (ICK), previously identified in ...
Yu, Bin, Millhauser, Glenn L.
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Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
, 2019 Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
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Loop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and Antagonism [PDF]
Journal of Molecular Biology, 2010 Agouti-related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play critical roles in energy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate melanocortin receptors. Signaling specificity is mediated in part through receptor binding selectivity brought about by alterations in the ...
Mira P, Patel +5 more
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Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
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Reply to Braasch and Postlethwait: Evolutionary origin of the teleost A2 agouti genes ( agouti signaling protein 2 and agouti-related protein 2 ) remains unclear [PDF]
Proceedings of the National Academy of Sciences, 2011 Tetrapods express one agouti gene [agouti signaling protein (asip)] in the skin regulating pigmentation and a second [agouti-related protein (agrp)] in the brain regulating energy homeostasis. In contrast, most teleosts have four genes encoding agouti-type proteins.
Helgi B. Schiöth +2 more
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Frontiers in Neuroscience, 2018 Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed.
Vance L. Trudeau
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Liver Research, 2023 Alcohol-related liver disease (ALD) became an important health issue worldwide. Following chronic alcohol consumption, the development of ALD might be caused by metabolic and immunologic factors, such as reactive oxygen species (ROS) and pro-inflammatory
Tom Ryu +4 more
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Detecting epistasis via Markov bases [PDF]
, 2010 Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
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