Results 71 to 80 of about 17,214 (224)

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption

Journal of Lipid Research, 2010
Fat is delivered to tissues by apoB-containing lipoproteins synthesized in the liver and intestine with the help of an intracellular chaperone, microsomal triglyceride transfer protein (MTP).
Jahangir Iqbal, Xiaosong Li, Benny Hung-Junn Chang, Lawrence Chan, Gary J. Schwartz, Streamson C. Chua, Jr., M. Mahmood Hussain   +6 more
doaj   +1 more source

Agouti Signaling Protein Stimulates Islet Amyloid Polypeptide (Amylin) Secretion in Pancreatic β-Cells

Experimental Biology and Medicine, 2001
Ectopic overexpression of the murine agouti gene results in yellow coat color, obesity, hyperinsulinemia, and type II diabetes. We have shown the human homologue of agouti (agouti signaling protein; ASP) to regulate human adipocyte metabolism and lipid storage via a Ca2+-dependent mechanism.
B, Xue, M B, Zemel
openaire   +2 more sources

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, EarlyView.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source

Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons

Molecular Metabolism, 2016
Objective: Adiponectin receptors (AdipoRs) are located on neurons of the hypothalamus involved in metabolic regulation – including arcuate proopiomelanocortin (Pomc) and Neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons.
Jia Sun, Yong Gao, Ting Yao, Yiru Huang, Zhenyan He, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hongbo Guo, Jianqun Yan, Yongsheng Chang, Hong Chen, Philipp E. Scherer, Tiemin Liu, Kevin W. Williams   +14 more
doaj   +1 more source

The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

Frontiers in Neuroscience, 2022
Schizophrenia (SCZ) is a serious mental illness that affects 1% of people worldwide. SCZ is associated with a higher risk of developing metabolic disorders such as obesity.
Ruqin Zhou, Meng He, Jun Fan, Ruoxi Li, Yufeng Zuo, Benben Li, Guanbin Gao, Taolei Sun   +7 more
doaj   +1 more source

The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]

, 2005
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Al-Qassab, H., Al-Qassab, H., Ashford, M.L.J., Ashford, M.L.J., Barsh, G.S., Barsh, G.S., Batterham, R.L., Batterham, R.L., Bedford, D.C., Bedford, D.C., Bell, J.D., Bell, J.D., Choudhury, A.I., Choudhury, A.I., Claret, M., Claret, M., Clements, M., Clements, M., Diakonov, I., Diakonov, I., Heffron, H., Heffron, H., Hisadome, K., Hisadome, K., MacColl, G., MacColl, G., Moosajee, V., Moosajee, V., Selman, C., Selman, C., Simmgen, M., Simmgen, M., Smith, M.A., Smith, M.A., Speakman, J.R., Speakman, J.R., Withers, D.J., Withers, D.J., Xu, A.W., Xu, A.W.   +39 more
core   +5 more sources

The role of agomelatine in appetite regulation and body weight in rats

Experimental Physiology, EarlyView.
Abstract The hypothalamic nuclei play a central role in the synthesis of anorexigenic and orexigenic neuropeptides, which are regulated by peripheral hormones, like leptin and ghrelin. Melatonergic receptors (MT1/MT2) are prominently expressed in the arcuate nucleus of the hypothalamus – an essential hub for appetite control – and in peripheral ...
Engin Korkmaz, Yavuz Erden, Çiğdem Tekin, Suat Tekin   +3 more
wiley   +1 more source

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

eLife, 2016
Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate structural connections with neurons, their roles in energy homeostasis are less known.
Naiyan Chen, Hiroki Sugihara, Jinah Kim, Zhanyan Fu, Boaz Barak, Mriganka Sur, Guoping Feng, Weiping Han   +7 more
doaj   +1 more source

Hypothalamic mitochondria in energy homeostasis and obesity [PDF]

, 2016
Citation: Guo X, Wu L, Wang W, Medeiros DM, Clarke S, et al.(2016) Hypothalamic mitochondria in energy homeostasis and obesity. Integr Mol Med 3: DOI: 10.15761/IMM.1000209.Obesity, which is largely due to energy imbalance, has emerged as one of the most ...
Chowanadisai, Winyoo, Clarke, Stephen, Guo, Xin, Lin, Dingbo, Lucas, Edralin, Medeiros, Denis M., Smith, Brenda, Wang, Weiqun, Wu, Lei   +8 more
core   +1 more source