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Airway epithelium in lung transplantation: a potential actor for post-transplant complications? [PDF]
European Respiratory ReviewLung transplantation, a critical intervention for end-stage lung diseases, is frequently challenged by post-transplant complications. Indeed, primary graft dysfunction, anastomotic complications, infections and acute and chronic rejections pose ...
Jules Milesi +3 more
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Cross-species comparison of airway epithelium transcriptomics. [PDF]
HeliyonStudies of lung transcriptomics across species are essential for understanding the complex biology and disease mechanisms of this vital organ. Single-cell RNA sequencing (scRNA-seq) has emerged as a key tool for understanding cell dynamics across various species. However, comprehensive cross-species comparisons are limited.
Gui B +5 more
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Engineering Airway Epithelium [PDF]
Journal of Biomedicine and Biotechnology, 2012 Airway epithelium is constantly presented with injurious signals, yet under healthy circumstances, the epithelium maintains its innate immune barrier and mucociliary elevator function. This suggests that airway epithelium has regenerative potential (I. R. Telford and C. F. Bridgman, 1990).
John P. Soleas +4 more
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Allicin Facilitates Airway Surface Liquid Hydration by Activation of CFTR
Frontiers in Pharmacology, 2022 Airway epithelium plays critical roles in regulating airway surface liquid (ASL), the alteration of which causes mucus stasis symptoms. Allicin is a compound released from garlic and harbors the capacity of lung-protection.
Zhuo-Er Qiu +14 more
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Airway Epithelium: A Neglected but Crucial Cell Type in Asthma Pathobiology
Diagnostics, 2023 The features of allergic asthma are believed to be mediated mostly through the Th2 immune response. In this Th2-dominant concept, the airway epithelium is presented as the helpless victim of Th2 cytokines. However, this Th2-dominant concept is inadequate
Sabita Singh +4 more
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The human airway epithelial basal cell transcriptome. [PDF]
PLoS ONE, 2011 The human airway epithelium consists of 4 major cell types: ciliated, secretory, columnar and basal cells. During natural turnover and in response to injury, the airway basal cells function as stem/progenitor cells for the other airway cell types.
Neil R Hackett +8 more
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APL Bioengineering, 2023 The airway epithelium lining the luminal surface of the respiratory tract creates a protective barrier that ensures maintenance of tissue homeostasis and prevention of respiratory diseases.
Jiawen Chen +7 more
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Frontiers in Immunology, 2023 High mobility group box 1 (HMGB1), a ubiquitous chromatin-binding protein required for gene transcription regulation, is released into the extracellular microenvironment by various structural and immune cells, where it is known to act as an alarmin. Here,
Yun Mao, Sonika Patial, Yogesh Saini
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Conserved Mechanisms in the Formation of the Airways and Alveoli of the Lung
Frontiers in Cell and Developmental Biology, 2021 Branching is an intrinsic property of respiratory epithelium that can be induced and modified by signals emerging from the mesenchyme. However, during stereotypic branching morphogenesis of the airway, the relatively thick upper respiratory epithelium ...
David Warburton
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Apical-Out Human Airway Organoids Modeling SARS-CoV-2 Infection
Viruses, 2023 The respiratory epithelium, particularly the airway epithelium, is the primary infection site for respiratory pathogens. The apical surface of epithelial cells is constantly exposed to external stimuli including invading pathogens. Efforts have been made
Man Chun Chiu +8 more
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