Results 11 to 20 of about 60,557 (265)

Establishing Bipotential Human Lung Organoid Culture System and Differentiation to Generate Mature Alveolar and Airway Organoids

Bio-Protocol, 2023
A robust in vitro model of the human respiratory epithelium, including the alveolar and the airway epithelium, is essential for understanding the biology and pathology of the human respiratory system.
Man Chun Chiu, Cun Li, Yifei Yu, Xiaojuan Liu, Jingjing Huang, Zhixin Wan, Kwok Yung Yuen, Jie Zhou   +7 more
doaj   +1 more source

Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease

EBioMedicine, 2020
Background: Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide.
François M. Carlier, Sébastien Dupasquier, Jérôme Ambroise, Bruno Detry, Marylène Lecocq, Charline Biétry–Claudet, Yassine Boukala, Jean-Luc Gala, Caroline Bouzin, Stijn E. Verleden, Delphine Hoton, Sophie Gohy, Bertrand Bearzatto, Charles Pilette   +13 more
doaj   +1 more source

Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis.

PLoS Pathogens, 2022
Influenza A virus (IAV) preferentially infects conducting airway and alveolar epithelial cells in the lung. The outcome of these infections is impacted by the host response, including the production of various cytokines, chemokines, and growth factors ...
Bradley E Hiller, Yongjun Yin, Yi-Chieh Perng, Ítalo de Araujo Castro, Lindsey E Fox, Marissa C Locke, Kristen J Monte, Carolina B López, David M Ornitz, Deborah J Lenschow   +9 more
doaj   +1 more source

Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional

Nature Communications, 2021
Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear.
Ian T. Stancil, Jacob E. Michalski, Duncan Davis-Hall, Hong Wei Chu, Jin-Ah Park, Chelsea M. Magin, Ivana V. Yang, Bradford J. Smith, Evgenia Dobrinskikh, David A. Schwartz   +9 more
doaj   +1 more source

Airway epithelium expresses interleukin-18 [PDF]

European Respiratory Journal, 1999
Interleukin (IL)-18 is an interferon (IFN)-gamma-inducing cytokine suggested to be important in regulating inflammatory responses. This study investigated the pulmonary expression of IL-18 under conditions characterized by T-helper (Th)1 (lipopolysaccharide (LPS) treatment/sarcoidosis) and Th2 (ovalbumin (OVA) challenge/asthma) cytokine production.
L A, Cameron, R A, Taha, A, Tsicopoulos, M, Kurimoto, R, Olivenstein, B, Wallaert, E M, Minshall, Q A, Hamid   +7 more
openaire   +2 more sources

Rhinovirus and COPD airway epithelium [PDF]

Pulmonary and Critical Care Medicine, 2017
Chronic Obstructive Pulmonary Disease (COPD) is characterized by irreversible airflow limitation. It is a global disease and expected to be the third leading cause of death. Respiratory exacerbations are associated with increased mortality and morbidity in this patient population.
Nicole, Owuor, Nisha, Nalamala, Joao Antonio, Gimenes, Uma S, Sajjan   +3 more
openaire   +2 more sources

Airway Epithelial-Derived Immune Mediators in COVID-19

Viruses, 2023
The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that causes COVID-19.
Tony J. F. Guo, Gurpreet K. Singhera, Janice M. Leung, Delbert R. Dorscheid   +3 more
doaj   +1 more source

Disparate oxidant gene expression of airway epithelium compared to alveolar macrophages in smokers

Respiratory Research, 2009
Background The small airway epithelium and alveolar macrophages are exposed to oxidants in cigarette smoke leading to epithelial dysfunction and macrophage activation. In this context, we asked: what is the transcriptome of oxidant-related genes in small
Hackett Neil R, Harvey Ben-Gary, Carolan Brendan J, O'Connor Timothy P, Cassano Patricia A, Crystal Ronald G   +5 more
doaj   +1 more source

SARS-CoV-2 Infection of Airway Epithelium Triggers Pulmonary Endothelial Cell Activation and Senescence Associated with Type I IFN Production

Cells, 2022
Airway epithelial cells represent the main target of SARS-CoV-2 replication but several pieces of evidence suggest that endothelial cells (ECs), lining pulmonary blood vessels, are key players in lung injury in COVID-19 patients.
Veronica Bordoni, Davide Mariotti, Giulia Matusali, Francesca Colavita, Eleonora Cimini, Giuseppe Ippolito, Chiara Agrati   +6 more
doaj   +1 more source

Surprises from the airway epithelium [PDF]

Proceedings of the National Academy of Sciences, 2001
The epithelium of the pulmonary airways subserves a wide range of functions, from providing a barrier against inhaled particles and pathogens to transmitting signals to subepithelial cells. Given the central place of the epithelium in respiratory tract pathophysiology, the molecular determinants of epithelial function are appropriately the focus of ...
openaire   +2 more sources