Results 21 to 30 of about 60,557 (265)

Spatial characteristics of neutrophils and eosinophils in conducting airway mucosa of mice with induced allergic airway inflammation

Медицинская иммунология, 2023
Daily inhaled antigens induce cellular immune response in the airways. In case of allergens, allergic airway inflammation is usually represented by eosinophils, however, neutrophil infiltration is also observed during severe asthma.
M. A. Shevchenko, D. E. Murova, E. A. Servuli   +2 more
doaj   +1 more source

Lung epithelium development and airway regeneration

Frontiers in Cell and Developmental Biology, 2022
The lung is composed of a highly branched airway structure, which humidifies and warms the inhaled air before entering the alveolar compartment. In the alveoli, a thin layer of epithelium is in close proximity with the capillary endothelium, allowing for an efficient exchange of oxygen and carbon dioxide.
Evelien Eenjes, Dick Tibboel, Rene M.H. Wijnen, Robbert J. Rottier, Robbert J. Rottier   +4 more
openaire   +4 more sources

Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium

Respiratory Research, 2010
Background The production of gamma-amino butyric acid (GABA) is dependent on glutamate decarboxylases (GAD65 and GAD67), the enzymes that catalyze the decarboxylation of glutamate to GABA.
Strulovici-Barel Yael, Salit Jacqueline, Ferris Barbara, Wang Rui, Wang Guoqing, Hackett Neil R, Crystal Ronald G   +6 more
doaj   +1 more source

Cell-intrinsic differences between human airway epithelial cells from children and adults

iScience, 2022
Summary: The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related ...
Elizabeth F. Maughan, Robert E. Hynds, Adam Pennycuick, Ersilia Nigro, Kate H.C. Gowers, Celine Denais, Sandra Gómez-López, Kyren A. Lazarus, Jessica C. Orr, David R. Pearce, Sarah E. Clarke, Dani Do Hyang Lee, Maximillian N.J. Woodall, Tereza Masonou, Katie-Marie Case, Vitor H. Teixeira, Benjamin E. Hartley, Richard J. Hewitt, Chadwan Al Yaghchi, Gurpreet S. Sandhu, Martin A. Birchall, Christopher O’Callaghan, Claire M. Smith, Paolo De Coppi, Colin R. Butler, Sam M. Janes   +25 more
doaj   +1 more source

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

Allergology International, 2018
Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation.
Yasuhiro Gon, Shu Hashimoto
doaj   +1 more source

Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers

BMC Medical Genomics, 2012
Background Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways.
Wang Guoqing, Xu Zhibo, Wang Rui, Al-Hijji Mohammed, Salit Jacqueline, Strulovici-Barel Yael, Tilley Ann E, Mezey Jason G, Crystal Ronald G   +8 more
doaj   +1 more source

The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium

Respiratory Research, 2019
Background Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction.
Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang, Qin Wang   +5 more
doaj   +1 more source

SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

eLife, 2021
SOX2 expression levels are crucial for the balance between maintenance and differentiation of airway progenitor cells during development and regeneration. Here, we describe patterning of the mouse proximal airway epithelium by SOX21, which coincides with
Evelien Eenjes, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Gabriela G Edel, Floor Benthem, Lisette de Kreij-de Bruin, Marco Schnater, Dick Tibboel, Jennifer Collins, Robbert J Rottier   +9 more
doaj   +1 more source

Apoptosis and the Airway Epithelium [PDF]

Journal of Allergy, 2011
The airway epithelium functions as a barrier and front line of host defense in the lung. Apoptosis or programmed cell death can be elicited in the epithelium as a response to viral infection, exposure to allergen or to environmental toxins, or to drugs.
openaire   +2 more sources

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

Cell Discovery, 2022
The airways and alveoli of the human respiratory tract are lined by two distinct types of epithelium, which are the primary targets of respiratory viruses.
Man Chun Chiu, Cun Li, Xiaojuan Liu, Yifei Yu, Jingjing Huang, Zhixin Wan, Ding Xiao, Hin Chu, Jian-Piao Cai, Biao Zhou, Ko-Yung Sit, Wing-Kuk Au, Kenneth Kak-Yuen Wong, Gang Li, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Zhiwei Chen, Shibo Jiang, Hans Clevers, Kwok Yung Yuen, Jie Zhou   +20 more
doaj   +1 more source