Results 11 to 20 of about 271,362 (308)

Parkin Promotes Airway Inflammatory Response to Interferon Gamma

Biomedicines, 2023
Purpose: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment.
Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Taylor Nichols, Hong Wei Chu   +4 more
doaj   +1 more source

Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. [PDF]

PLoS ONE, 2011
Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway remodeling and fibrosis but the mechanisms involved are not clear.
Jill R Johnson, Abraham Roos, Tove Berg, Magnus Nord, Jonas Fuxe   +4 more
doaj   +1 more source

A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke–induced neutrophilic and eosinophilic airway inflammation

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced ...
David B. Peden, MD, Martha Almond, RRT, Christian Brooks, BS, Carole Robinette, MS, Heather Wells, MS, Allison Burbank, MD, Michelle Hernandez, MD, Alan Hinderliter, MD, Melissa Caughey, PhD, Qing Jiang, PhD, Qianyue Wang, MS, Haolin Li, BSPH, Haibo Zhou, PhD, Neil Alexis, PhD   +13 more
doaj   +1 more source

Annexin A2 Mediates Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Binding to Eukaryotic Cells

mBio, 2014
Mycoplasma pneumoniae synthesizes a novel human surfactant protein A (SP-A)-binding cytotoxin, designated community-acquired respiratory distress syndrome (CARDS) toxin, that exhibits ADP-ribosylating and vacuolating activities in mammalian cells and is ...
Sudha R. Somarajan, Fadi Al-Asadi, Kumaraguruparan Ramasamy, Lavanya Pandranki, Joel B. Baseman, T. R. Kannan   +5 more
doaj   +1 more source

CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice

Frontiers in Immunology, 2020
RationaleIncreased IL-8 levels and neutrophil accumulation in the airways are common features found in patients affected by pulmonary diseases such as Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD.
Matheus Silverio Mattos, Maximiliano Ruben Ferrero, Lucas Kraemer, Gabriel Augusto Oliveira Lopes, Diego Carlos Reis, Geovanni Dantas Cassali, Fabricio Marcus Silva Oliveira, Laura Brandolini, Marcello Allegretti, Cristiana Couto Garcia, Marco Aurélio Martins, Mauro Martins Teixeira, Remo Castro Russo, Remo Castro Russo   +13 more
doaj   +1 more source

Novel Lung Growth Strategy with Biological Therapy Targeting Airway Remodeling in Childhood Bronchial Asthma

Children, 2022
Anti-inflammatory therapy, centered on inhaled steroids, suppresses airway inflammation in asthma, reduces asthma mortality and hospitalization rates, and achieves clinical remission in many pediatric patients.
Mitsuru Tsuge, Masanori Ikeda, Hirokazu Tsukahara   +2 more
doaj   +1 more source

Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation [PDF]

, 2016
Immunological cross talk between mucosal tissues such as the intestine and the lung is poorly defined during homeostasis and disease. Here, we show that a low-dose infection with the intestinally restricted helminth parasite Trichuris muris results in ...
Antignano, Frann, Burrows, Kyle, Chenery, Alistair L., Perona-Wright, Georgia, Scheer, Sebastian, Zaph, Colby   +5 more
core   +2 more sources

ADP-Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity

mBio, 2014
The inflammasome is a major regulator of inflammation through its activation of procaspase-1, which cleaves prointerleukin-1β (pro-IL-1β) into its mature form.
Santanu Bose, Jesus A. Segovia, Sudha R. Somarajan, Te-Hung Chang, T. R. Kannan, Joel B. Baseman   +5 more
doaj   +1 more source

Role of FK506-sensitive signals in asthmatic lung inflammation

Frontiers in Immunology, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Chihiro Tomiaki, Kosuke Miyauchi, Sewon Ki, Yoshie Suzuki, Narumi Suzuki, Hiroshi Morimoto, Yohei Mukoyama, Masato Kubo, Masato Kubo   +8 more
doaj   +1 more source

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma [PDF]

, 2016
Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial ...
Al-Riyami, L., Coltherd, J. C., Harnett, M. M., Harnett, W., Lawrie, R. E., Rodgers, D. T., Suckling, C. J.   +6 more
core   +1 more source