Leukotrienes and airway inflammation [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2011 Asthma is a common chronic inflammatory disease of the airways characterized by airway obstruction and hyperresponsiveness. Leukotrienes (LTs) are lipid mediators that contribute to many aspects of asthma pathogenesis. As the LT pathway is relatively steroid-resistant, its blockade by alternative strategies is a desirable component of asthma management.
Katsuhide, Okunishi, Marc, Peters-Golden
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Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. [PDF]
, 2017 The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD).
Cheng, D +12 more
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High-fat diet and palmitic acid amplify airway type 2 inflammation
Frontiers in Allergy, 2023 IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear.
Kris Genelyn Dimasuay +5 more
doaj +1 more source
ERJ Open Research, 2018 Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already evoke a MC response during ...
Cecilia K. Andersson +10 more
doaj +1 more source
NETopathic Inflammation in Chronic Obstructive Pulmonary Disease and Severe Asthma
Frontiers in Immunology, 2019 Neutrophils play a central role in innate immunity, inflammation, and resolution. Unresolving neutrophilia features as a disrupted inflammatory process in the airways of patients with chronic obstructive pulmonary disease (COPD) and severe asthma.
Mohib Uddin +7 more
doaj +1 more source
Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. [PDF]
PLoS ONE, 2013 Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. However, the initiating factor that links airway inflammation to remodeling is unknown.
Zhuang-Gui Chen +6 more
doaj +1 more source
The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. [PDF]
, 2012 BackgroundLipoprotein-associated phospholipase A2 (Lp-PLA2)/platelet-activating factor acetylhydrolase (PAF-AH) has been implicated in the pathogenesis of cardiovascular disease.
Fehrenbach, Melane L +8 more
core +2 more sources
Медицинская иммунология, 2023 Daily inhaled antigens induce cellular immune response in the airways. In case of allergens, allergic airway inflammation is usually represented by eosinophils, however, neutrophil infiltration is also observed during severe asthma.
M. A. Shevchenko +2 more
doaj +1 more source
Endogenous IL-33 and Its Autoamplification of IL-33/ST2 Pathway Play an Important Role in Asthma. [PDF]
, 2020 IL-33 and its receptor ST2 are contributing factors to airway inflammation and asthma exacerbation. The IL-33/ST2 signaling pathway is involved in both the onset and the acute exacerbations of asthma.
Dumouchel, Justin P +5 more
core
Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge [PDF]
, 2012 Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose, Markus A. +5 more
core +2 more sources