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Airway Smooth Muscle and Asthma
Cells, 2023 Airway smooth muscle (ASM) was first described in 1804 by Franz Daniel Reisseisen (as related by Otis (1983)) [...]
Steven An, Dale D. Tang
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Airway Remodeling and Airway Smooth Muscle in Asthma
Allergology International, 2006 Airway remodeling in asthma has been recognized as structural changes of airways such as smooth muscle hypertrophy (an increase in size of airway smooth muscle cells) and hyperplasia (an increase in the number of airway smooth muscle cells), thickening ...
Mitsuru Munakata
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Inflammation signals airway smooth muscle cell proliferation in asthma pathogenesis [PDF]
Multidisciplinary Respiratory Medicine, 2013 Background Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be due to an up-
Khan Mohammad Afzal
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Detecting the Multiomics Signatures of Factor-Specific Inflammatory Effects on Airway Smooth Muscles
Frontiers in Genetics, 2021 Smooth muscles are a specific muscle subtype that is widely identified in the tissues of internal passageways. This muscle subtype has the capacity for controlled or regulated contraction and relaxation.
Yu-Hang Zhang +7 more
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Bronchial smooth muscle cell in asthma: where does it fit?
BMJ Open Respiratory Research, 2022 Asthma is a frequent respiratory condition whose pathophysiology relies on altered interactions between bronchial epithelium, smooth muscle cells (SMC) and immune responses.
Gervaise Loirand +5 more
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Airway smooth muscle function in asthma
Frontiers in Physiology, 2022 Known to have affected around 340 million people across the world in 2018, asthma is a prevalent chronic inflammatory disease of the airways. The symptoms such as wheezing, dyspnea, chest tightness, and cough reflect episodes of reversible airway ...
Dora (Jun Ping) Xiong +5 more
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Airway Smooth Muscle Regulated by Oxidative Stress in COPD
Antioxidants, 2023 Since COPD is a heterogeneous disease, a specific anti-inflammatory therapy for this disease has not been established yet. Oxidative stress is recognized as a major predisposing factor to COPD related inflammatory responses, resulting in pathological ...
Hiroaki Kume +3 more
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MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Current asthma therapies remain unsatisfactory for controlling airway remodelling in asthma. MicroRNA-21 is a key player in asthma pathogenesis, but the molecular mechanisms underlying its effects on airway remodelling are not completely ...
Jung Hur +4 more
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The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. [PDF]
PLoS ONE, 2013 BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by
Michael Roth +5 more
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Regulation of human airway smooth muscle cell migration and relevance to asthma
Respiratory Research, 2017 Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass.
Brittany Salter +4 more
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