Scientific Reports, 2021 Although HHIP locus has been consistently associated with the susceptibility to COPD including airway remodeling and emphysema in genome-wide association studies, the molecular mechanism underlying this genetic association remains incompletely understood.
Yan Li +10 more
doaj +2 more sources
Effect of acute and chronic pressure-threshold inspiratory muscle training on upper and lower airway function [PDF]
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.There is evidence to suggest that inspiratory muscle training (IMT) may influence the functional properties of the muscles of the upper (UA) and lower (LA ...
How, Stephen Christopher
core +8 more sources
Pro-inflammatory cytokines induce c-fos expression followed by IL-6 release in human airway smooth muscle cells [PDF]
Mediators of Inflammation, 2001 Background: Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation.
Sue McKay +5 more
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Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]
, 2014 Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core +1 more source
Na+/Ca2+ Exchanger 1 in Airway Smooth Muscle of Allergic Inflammation Mouse Model
Frontiers in Pharmacology, 2018 Cytosolic free Ca2+ ([Ca2+]cyt) is essential for airway contraction, secretion and remodeling. [Ca2+]cyt homeostasis is controlled by several critical molecules, one of which is the Na+/Ca2+ exchanger 1 (NCX1) in the plasma membrane.
Jiexia Wen +7 more
doaj +1 more source
Bronchial epithelial and airway smooth muscle cell interactions in health and disease
Heliyon, 2023 Chronic pulmonary diseases such as asthma, COPD, and Idiopathic pulmonary fibrosis are significant causes of mortality and morbidity worldwide. Currently, there is no radical treatment for many chronic pulmonary diseases, and the treatment options focus ...
Reshed Abohalaka
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RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma
Journal of Pharmacological Sciences, 2010 .: Airway hyperresponsiveness to nonspecific stimuli is one of the characteristic features of allergic bronchial asthma. An elevated contractility of bronchial smooth muscle has been considered as one of the causes of the airway hyperresponsiveness.
Yoshihiko Chiba +2 more
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FASEB BioAdvances, 2022 Asthma is a chronic inflammatory disorder of the lower airways characterized by modulation of airway smooth muscle (ASM) function. Infiltration of smooth muscle by inflammatory mediators is partially regulated by transmembrane integrins and the major ...
Mariam A. Ba +6 more
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Patterning the embryonic pulmonary mesenchyme
iScience, 2022 Summary: Smooth muscle guides the morphogenesis of several epithelia during organogenesis, including the mammalian airways. However, it remains unclear how airway smooth muscle differentiation is spatiotemporally patterned and whether it originates from ...
Katharine Goodwin +5 more
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Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model. [PDF]
PLoS ONE, 2014 BackgroundAllergic asthma is associated with chronic airway inflammation and progressive airway remodelling. However, the dynamics of the development of these features and their spontaneous and pharmacological reversibility are still poorly understood ...
Mohammed Alrifai +6 more
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