Results 51 to 60 of about 903,463 (268)
On Modules Over Motivic Ring Spectra
, 2019 In this note, we provide an axiomatic framework that characterizes the stable $\infty$-categories that are module categories over a motivic spectrum. This is done by invoking Lurie's $\infty$-categorical version of the Barr--Beck theorem.
Elmanto, Elden, Kolderup, Håkon
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FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Effects of MRE11 on Apoptosis and Proliferation of Esophageal Squamous Cancer Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effect of MRE11 on the proliferation and apoptosis of esophageal squamous cancer cells and its molecular mechanism. Methods MRE11 expression was downregulated by MRE11 siRNA transfection in esophageal squamous cancer cells ...
ZHANG Yan +4 more
doaj +1 more source
Algebraic K-theory of quotient stacks
, 2017 We prove some fundamental results like localization, excision, Nisnevich descent and the Mayer-Vietoris property for equivariant regular blow-up for the equivariant K-theory of schemes with an affine group scheme action. We also show that the equivariant
Krishna, Amalendu, Ravi, Charanya
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Cardiosphere-derived cells demonstrate metabolic flexibility that Is influenced by adhesion status [PDF]
, 2017 Adult stem cells demonstrate metabolic flexibility that is regulated by cell adhesion status. The authors demonstrate that adherent cells primarily utilize glycolysis, whereas suspended cells rely on oxidative phosphorylation for their ATP needs.
Abraham, M. Roselle +13 more
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Effect of ellagic acid on BDNF/PI3K/AKT-mediated signaling pathways in mouse models of depression [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): The aim of this study is to investigate the possible role of the hippocampal BDNF-PI3K-AKT signaling pathway in the antidepressant-like activity of ellagic acid (EA) in mice.Materials and Methods: Male BALB/C mice were divided into 5 groups;
Aslı Bedel, Coskun Usta
doaj +1 more source
G-theory of root stacks and equivariant K-theory
, 2018 Using the description of the category of quasi-coherent sheaves on a root stack given in the paper of N. Borne and A. Vistoli, we study the G-theory of root stacks via localisation methods.
Dhillon, A., Kobyzev, I.
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer [PDF]
, 2016 In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/
Bennett, Lindsay +7 more
core +3 more sources