Results 51 to 60 of about 972,716 (314)
Effects of MRE11 on Apoptosis and Proliferation of Esophageal Squamous Cancer Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effect of MRE11 on the proliferation and apoptosis of esophageal squamous cancer cells and its molecular mechanism. Methods MRE11 expression was downregulated by MRE11 siRNA transfection in esophageal squamous cancer cells ...
ZHANG Yan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Effect of ellagic acid on BDNF/PI3K/AKT-mediated signaling pathways in mouse models of depression [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): The aim of this study is to investigate the possible role of the hippocampal BDNF-PI3K-AKT signaling pathway in the antidepressant-like activity of ellagic acid (EA) in mice.Materials and Methods: Male BALB/C mice were divided into 5 groups;
Aslı Bedel, Coskun Usta
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On Modules Over Motivic Ring Spectra
, 2019 In this note, we provide an axiomatic framework that characterizes the stable $\infty$-categories that are module categories over a motivic spectrum. This is done by invoking Lurie's $\infty$-categorical version of the Barr--Beck theorem.
Elmanto, Elden, Kolderup, Håkon
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Algebraic K-theory of quotient stacks
, 2017 We prove some fundamental results like localization, excision, Nisnevich descent and the Mayer-Vietoris property for equivariant regular blow-up for the equivariant K-theory of schemes with an affine group scheme action. We also show that the equivariant
Krishna, Amalendu, Ravi, Charanya
core +1 more source
A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]
, 2017 Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas +5 more
core +3 more sources
Correction to: Cartilage Endplate Stem Cells Inhibit Intervertebral Disc Degeneration by Releasing Exosomes to Nucleus Pulposus Cells to Activate Akt/Autophagy [PDF]
, 2023 openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
G-theory of root stacks and equivariant K-theory
, 2018 Using the description of the category of quasi-coherent sheaves on a root stack given in the paper of N. Borne and A. Vistoli, we study the G-theory of root stacks via localisation methods.
Dhillon, A., Kobyzev, I.
core +1 more source