Results 191 to 200 of about 614,051 (372)

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

RNA codewords and protein synthesis, 8. Nucleotide sequences of synonym codons for arginine, valine, cysteine, and alanine. [PDF]

, 1965
Richard Brimacombe, Joel S. Trupin, M Nirenberg, Philip Leder, Merton Bernfield, T. Jaouni   +5 more
openalex   +1 more source

CPL‐Diff: A Diffusion Model for De Novo Design of Functional Peptide Sequences with Fixed Length

Advanced Science, EarlyView.
This study presents a diffusion model for generating functional peptide sequence lengths using mask control. The model can generate antimicrobial, antifungal, and antiviral peptides with specific lengths on demand. The model learns the structure of peptides better and generates peptides with better physicochemical properties, and the model has good ...
Zhenjie Luo, Aoyun Geng, Leyi Wei, Quan Zou, Feifei Cui, Zilong Zhang   +5 more
wiley   +1 more source

Studies on the Synthesis of Protein Analogus. XII-XV. XII. Preparation of Poly-γ-aminobutyric Acid and Poly-γ-aminobutyryl-DL-alanine.

, 1956
野口 順蔵, Tomoaki Hayakawa, 西村 衛, 石崎 重信, 下谷 忠義, 江幡 光雄, 斎藤 智夫, 中山 信一   +7 more
openalex   +2 more sources

Isocitritase, Glycine-Alanine Transaminase, and Development in Blastocladiella Emersonii [PDF]

, 1960
Howard D. McCurdy, Edward C. Cantino
openalex   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

UPTAKE OF RADIOACTIVE ALANINE IN VITRO INTO THE PROTEINS OF RAT LIVER FRACTIONS

, 1952
Philip Siekevitz
openalex   +1 more source

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

Advanced Science, EarlyView.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li   +11 more
wiley   +1 more source

Determination of Collisional Cross Section Using Microscale High-Field Asymmetric Waveform ion Mobility Spectroscopy-Mass Spectrometry (FAIMS-MS). [PDF]

Rapid Commun Mass Spectrom
Krasnova K, Creaser CS, Reynolds JC.
europepmc   +1 more source

INCORPORATION IN VITRO OF RADIOACTIVE CARBON FROM CARBOXYL-LABELED dl-ALANINE AND GLYCINE INTO PROTEINS OF NORMAL AND MALIGNANT RAT LIVERS

, 1948
Paul C. Zamecnik, Ivan D. Frantz, Robert B. Loftfield, Mary L. Stephenson   +3 more
openalex   +1 more source