Advanced Science, EarlyView.BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan +13 more
wiley +1 more source
Stable Nitrogen Isotope Analysis of Amino Acids by Orbitrap Mass Spectrometry: Application for Extraterrestrial Samples. [PDF]
Rapid Commun Mass SpectromMcIntosh OM +9 more
europepmc +1 more source
Response to 2-Deoxy-D-glucose and to Glucagon in “Ketotic Hypoglycemia” of Childhood: Evidence for Epinephrine Deficiency and Altered Alanine Availability [PDF]
, 1973 Pierre C. Sizonenko +5 more
openalex +1 more source
Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Advanced Science, EarlyView.Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
Bioaccessibility and Transformation of Conjugated Benzotriazole Phytometabolites during In Vitro Digestion: Implications for Exposure from Recycled Irrigation Water. [PDF]
Environ Sci TechnolChowdhury S, LeFevre GH.
europepmc +1 more source
Conformational analysis of dipeptides in aqucous solution. II. Molecular structure of glycine and alanine dipeptides by depolarized raleigh scattering and laser Raman spectroscopy [PDF]
, 1973 M. Avignon +2 more
openalex +1 more source
Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair
Advanced Science, EarlyView.A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao +7 more
wiley +1 more source
Hell's Itch: A Case Series of a Debilitating Post-Sunburn Pruritic Syndrome in a Healthy Young Adult. [PDF]
Reports (MDPI)Imokhai PO +4 more
europepmc +1 more source