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Alarmins in autoimmune diseases
Autoimmunity Reviews, 2022Alarmins are endogenous, constitutively expressed, chemotacting and immune activating proteins or peptides released because of non-programmed cell death (i.e. infections, trauma, etc). They are considered endogenous damage-associated molecular patterns (DAMPs), able to induce a sterile inflammation.
Danieli, Maria Giovanna +7 more
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Nature Reviews Immunology, 2014 [Alarmins and anti-alarmin biologics in asthma].
Tuberkuloz ve toraks, 2018Alarmins are endogenous, constitutively expressed, chemotactic, and immune activating proteins/peptides that are released as a result of degranulation, cell injury or death, or in response to immune induction. Alarmins are involved in a variety of processes including antimicrobial gene expression regulation, cellular homeostasis, wound healing ...
Begüm, Görgülü, Sevim, Bavbek
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Alarmins of the extracellular space
Seminars in Immunology, 2018The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and can perform specialized functions that can regulate a wide spectrum of processes ranging from propagation of disease ...
Jenna L, Dziki +2 more
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IL-33 is alarmin the uterus for labor
Immunity, 2023Timely labor is critical for both infant and maternal health, yet the mechanisms underlying the initiation of childbirth remain unclear. In this issue of Immunity, Siewiera et al. demonstrate a vital role for innate type 2 immune responses in controlling uterus-intrinsic onset of labor in mice.1.
Elizabeth A, Kennedy, Kellie Ann, Jurado
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Alarmins Initiate Host Defense
2007In response to infection and/or tissue injury, cells of the host innate immune system rapidly produce a variety of structurally distinct mediators (we elect to call alarmins) that not only function as potent effectors of innate defense but also act to alarm the immune system by promoting the recruitment and activation of host leukocytes through ...
Joost J, Oppenheim +3 more
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Alarmin Detection in Senescent Cells
2018Senescent cells secrete diverse array of proteins. One group of proteins, damage-associated molecular pattern (DAMP) proteins exhibit relocalization from inside to outside the cell. High Mobility Group Box 1 protein (HMGB1) is the founding DAMP member. HMGB1 relocalization from the nucleus provides a molecular signature during senescence.
Dong Eun, Kim, Albert R, Davalos
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Is HMGB1 an osteocyte alarmin?
Journal of Cellular Biochemistry, 2007AbstractThe death of osteocytes, the terminally differentiated cells of the osteoblast lineage that are embedded in bone and regulate remodeling, is significant to both normal and pathological bone resorption. Apoptotic osteocytes putatively release a clarion signal that enhances the development of the bone‐resorbing osteoclasts and targets their ...
Joseph P, Bidwell +2 more
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