Results 171 to 180 of about 7,888 (200)

The danger from within: alarmins in arthritis

Nature Reviews Rheumatology, 2016
Alarmins (also known as danger signals) are endogenous molecules that are released to the extracellular milieu after infection or tissue damage. Extracellular alarmins interact with specific receptors expressed by cells that are engaged in host defence to stimulate signalling pathways that result in initiation of innate and adaptive immune responses ...
Meriam, Nefla, Dirk, Holzinger, Francis, Berenbaum, Claire, Jacques   +3 more
openaire   +2 more sources

Alarmins: chemotactic activators of immune responses

Current Opinion in Immunology, 2005
The recruitment and activation of antigen-presenting cells are critical early steps in mounting an immune response. Many microbial components and endogenous mediators participate in this process. Recent studies have identified a group of structurally diverse multifunctional host proteins that are rapidly released following pathogen challenge and/or ...
Joost J, Oppenheim, De, Yang
openaire   +2 more sources

ApoC3: an ‘alarmin’ triggering sterile inflammation

Nature Immunology, 2019
NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.
Tao Gong, Rongbin Zhou
openaire   +2 more sources

Alarmin’ lymphoid developments

Science Signaling
The alarmin cytokine IL-33 stimulates the formation of immune hubs within otherwise “cold” tumors.
openaire   +2 more sources

Harnessing the Alarmin HMGN1 for Anticancer Therapy

Immunotherapy, 2015
Incipient cancer cells formed as a result of mutations of oncogene(s), tumor suppressor gene(s) and/or DNA repair gene(s) develop into malignant tumors depending on three processes. They acquire a higher rate of mutation due to increased sensitivity to endogenous and exogenous mutagenic agents or due to a breakdown in one or several components of the ...
De, Yang, Michael, Bustin, Joost J, Oppenheim   +2 more
openaire   +2 more sources

[Alarmins and surgical injury].

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 2019
Surgical intervention is an inseparable part of the management of serious surgical disease. However, surgery also presents a potential risk related to the so-called surgical injury causing immune response. When dysregulated the immune activation is able to cause local complications (i.e. wound dehiscence, impaired healing).
J, Máca, M, Peteja
openaire   +1 more source

Sounding the alarmins—The role of alarmin cytokines in asthma

Allergy: European Journal of Allergy and Clinical Immunology, 2023
Gail Gauvreau, Roma Sehmi, Boulet Louis-Philippe   +2 more
exaly  

The Yin and Yang of alarmin S100B in the protection of myocardium

Archives of Cardiovascular Diseases, 2021
, Gabriel Malka
exaly  

Gastric alarmin release: A warning signal in the development of gastric mucosal diseases

Frontiers in Immunology, 2022
Xuemei Liu, Shuji Terai, Biguang Tuo
exaly  

IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity

Cells, 2022
Corinne Cayrol, Cayrol Corinne
exaly