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Neutrophil and NET-driven pulmonary microvascular injury following myocardial injury: attenuation by S100A8/A9 inhibition

Lezama D, Katsoulis O, Marriott E, Grygielska B, Kavanagh D, Chen CH, Jackson MM, Jenkins E, Spencer K, Abimbola E, Kiwia N, Mahida R, Pavlovic D, McGettrick HM, Naidu B, Schiopu A, Thickett DR, Scott A, Johnston SL, Rayes J, Sapey E, Singanayagam A, El-Awaisi J.   +22 more
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Alarmins in autoimmune diseases

Autoimmunity Reviews, 2022
Alarmins are endogenous, constitutively expressed, chemotacting and immune activating proteins or peptides released because of non-programmed cell death (i.e. infections, trauma, etc). They are considered endogenous damage-associated molecular patterns (DAMPs), able to induce a sterile inflammation.
Danieli, Maria Giovanna, Antonelli, Eleonora, Piga, Mario Andrea, Claudi, Ilaria, Palmeri, Davide, Tonacci, Alessandro, Allegra, Alessandro, Gangemi, Sebastiano   +7 more
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[Alarmins and anti-alarmin biologics in asthma].

Tuberkuloz ve toraks, 2018
Alarmins are endogenous, constitutively expressed, chemotactic, and immune activating proteins/peptides that are released as a result of degranulation, cell injury or death, or in response to immune induction. Alarmins are involved in a variety of processes including antimicrobial gene expression regulation, cellular homeostasis, wound healing ...
Begüm, Görgülü, Sevim, Bavbek
openaire   +2 more sources

Alarmins Initiate Host Defense

2007
In response to infection and/or tissue injury, cells of the host innate immune system rapidly produce a variety of structurally distinct mediators (we elect to call alarmins) that not only function as potent effectors of innate defense but also act to alarm the immune system by promoting the recruitment and activation of host leukocytes through ...
Joost J, Oppenheim, Poonam, Tewary, Gonzalo, de la Rosa, De, Yang   +3 more
openaire   +2 more sources

Anti-alarmin approaches entering clinical trials

Current Opinion in Pulmonary Medicine, 2020
Purpose of review The alarmins, thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, are upstream regulators of T2 (type 2) inflammation and found to be expressed at high levels in airway epithelium of patients with T2 asthma. This review will summarize how alarmins regulate the inflamed asthmatic airways through
Gail M, Gauvreau, Lucie, White, Beth E, Davis   +2 more
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Alarmins of the extracellular space

Seminars in Immunology, 2018
The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and can perform specialized functions that can regulate a wide spectrum of processes ranging from propagation of disease ...
Jenna L, Dziki, George, Hussey, Stephen F, Badylak   +2 more
openaire   +2 more sources