Results 161 to 170 of about 1,269 (186)

IL-33 is alarmin the uterus for labor

Immunity, 2023
Timely labor is critical for both infant and maternal health, yet the mechanisms underlying the initiation of childbirth remain unclear. In this issue of Immunity, Siewiera et al. demonstrate a vital role for innate type 2 immune responses in controlling uterus-intrinsic onset of labor in mice.1.
Elizabeth A, Kennedy, Kellie Ann, Jurado
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Alarmins Initiate Host Defense

2007
In response to infection and/or tissue injury, cells of the host innate immune system rapidly produce a variety of structurally distinct mediators (we elect to call alarmins) that not only function as potent effectors of innate defense but also act to alarm the immune system by promoting the recruitment and activation of host leukocytes through ...
Joost J, Oppenheim, Poonam, Tewary, Gonzalo, de la Rosa, De, Yang   +3 more
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Alarmin Detection in Senescent Cells

2018
Senescent cells secrete diverse array of proteins. One group of proteins, damage-associated molecular pattern (DAMP) proteins exhibit relocalization from inside to outside the cell. High Mobility Group Box 1 protein (HMGB1) is the founding DAMP member. HMGB1 relocalization from the nucleus provides a molecular signature during senescence.
Dong Eun, Kim, Albert R, Davalos
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Is HMGB1 an osteocyte alarmin?

Journal of Cellular Biochemistry, 2007
AbstractThe death of osteocytes, the terminally differentiated cells of the osteoblast lineage that are embedded in bone and regulate remodeling, is significant to both normal and pathological bone resorption. Apoptotic osteocytes putatively release a clarion signal that enhances the development of the bone‐resorbing osteoclasts and targets their ...
Joseph P, Bidwell, Jieping, Yang, Alexander G, Robling   +2 more
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The danger from within: alarmins in arthritis

Nature Reviews Rheumatology, 2016
Alarmins (also known as danger signals) are endogenous molecules that are released to the extracellular milieu after infection or tissue damage. Extracellular alarmins interact with specific receptors expressed by cells that are engaged in host defence to stimulate signalling pathways that result in initiation of innate and adaptive immune responses ...
Meriam, Nefla, Dirk, Holzinger, Francis, Berenbaum, Claire, Jacques   +3 more
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Alarmins: chemotactic activators of immune responses

Current Opinion in Immunology, 2005
The recruitment and activation of antigen-presenting cells are critical early steps in mounting an immune response. Many microbial components and endogenous mediators participate in this process. Recent studies have identified a group of structurally diverse multifunctional host proteins that are rapidly released following pathogen challenge and/or ...
Joost J, Oppenheim, De, Yang
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ApoC3: an ‘alarmin’ triggering sterile inflammation

Nature Immunology, 2019
NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.
Tao Gong, Rongbin Zhou
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Alarmin’ lymphoid developments

Science Signaling
The alarmin cytokine IL-33 stimulates the formation of immune hubs within otherwise “cold” tumors.
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Harnessing the Alarmin HMGN1 for Anticancer Therapy

Immunotherapy, 2015
Incipient cancer cells formed as a result of mutations of oncogene(s), tumor suppressor gene(s) and/or DNA repair gene(s) develop into malignant tumors depending on three processes. They acquire a higher rate of mutation due to increased sensitivity to endogenous and exogenous mutagenic agents or due to a breakdown in one or several components of the ...
De, Yang, Michael, Bustin, Joost J, Oppenheim   +2 more
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[Alarmins and surgical injury].

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 2019
Surgical intervention is an inseparable part of the management of serious surgical disease. However, surgery also presents a potential risk related to the so-called surgical injury causing immune response. When dysregulated the immune activation is able to cause local complications (i.e. wound dehiscence, impaired healing).
J, Máca, M, Peteja
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