Results 61 to 70 of about 194,755 (364)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Oxidation of Aldehydes Used as Food Additives by Peroxynitrite

Antioxidants, 2023
Benzaldehyde and its derivatives are used as food supplements. These substances can be used mainly as flavorings or as antioxidants. Besides, peroxynitrite, an oxidizing agent, could be formed in canned food. Both species could react between them.
Clara I. Alcolado, Luis Garcia-Rio, Juan C. Mejuto, Inmaculada Moreno, Francisco J. Poblete, Juan Tejeda   +5 more
doaj   +1 more source

Insights on the role of acetaldehyde and other aldehydes in the odour and tactile nasal perception of red wine [PDF]

, 2021
Wine models with or without a dearomatised and lyophilized red wine extract containing a young red aroma base (control) plus one vector with one or several aroma compounds (unsaturated-aldehydes, saturated-aldehydes, benzaldehyde, isoamyl-alcohol ...
Ferreira, null [0000-0002-4353-2483], Sáenz-Navajas, null [0000-0001-7225-2272], Escudero, null, de-la-Fuente-Blanco, null [0000-0002-4093-900X], Arias-Pérez, null [0000-0002-0471-6159]   +4 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Molecular Response to Toxic Diatom-Derived Aldehydes in the Sea Urchin Paracentrotus lividus

Marine Drugs, 2014
Diatoms are dominant photosynthetic organisms in the world’s oceans and represent a major food source for zooplankton and benthic filter-feeders. However, their beneficial role in sustaining marine food webs has been challenged after the discovery that ...
Stefano Varrella, Giovanna Romano, Adrianna Ianora, Matt G. Bentley, Nadia Ruocco, Maria Costantini   +5 more
doaj   +1 more source

Exhaled Aldehydes as Biomarkers for Lung Diseases: A Narrative Review

Molecules, 2022
Breath analysis provides great potential as a fast and non-invasive diagnostic tool for several diseases. Straight-chain aliphatic aldehydes were repeatedly detected in the breath of patients suffering from lung diseases using a variety of methods, such ...
Maximilian Alexander Floss, Tobias Fink, Felix Maurer, Thomas Volk, Sascha Kreuer, Lukas Martin Müller-Wirtz   +5 more
doaj   +1 more source

Remarkable Diastereoselectivity in the Addition of Allylic and Unsaturated Diorganozinc Reagents to β-(N,N-Dialkylamino)-aldehydes

, 2016
1,3-Anti amino alcohols 5a−18a are obtained with high diastereoselectivity by use of diorganozinc reagents in additions to amino aldehydes 2a and 2b. The corresponding Grignard reagents exhibit low to modest diastereoselectivity.
Denis Kozhinov (3031350), Regina L. Soucy (3031347), Victor Behar (2724535)   +2 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The Regular Interaction Pattern among Odorants of the Same Type and Its Application in Odor Intensity Assessment

Sensors, 2017
The olfactory evaluation function (e.g., odor intensity rating) of e-nose is always one of the most challenging issues in researches about odor pollution monitoring.
Luchun Yan, Jiemin Liu, Shen Jiang, Chuandong Wu, Kewei Gao   +4 more
doaj   +1 more source