Results 101 to 110 of about 232,884 (341)

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients

Endocrine Regulations, 2020
Objective. The cytochrome 11B2 aldosterone synthase gene (CYP11B2) that links to aldosterone synthase enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes.
Sydorchuk Larysa, Dzhuryak Valentina, Sydorchuk Andrii, Levytska Svitlana, Petrynych Volodymyr, Knut Ruslan, Kshanovska Anna, Iftoda Oksana, Tkachuk Olexii, Kyfiak Petro, Popovich Andrii, Khomko Oleh, Sydorchuk Ruslan   +12 more
doaj   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

Chemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo, Rita de Cássia Vilhena da Silva, Valdir Cechinel Filho, Priscila de Souza   +3 more
wiley   +1 more source

Development and application of an UHPLC-MS/MS method for the simultaneous determination of 17 steroidal hormones in equine serum [PDF]

, 2017
A new, fast and simple analytical method that is able to identify and quantify simultaneously 17 steroid hormones and metabolites (Pregnenolone, 17-OH-Pregnenolone, Progesterone, 17-OH Progesterone, Androsterone, Androstenedione, DHEA, DHEAS ...
Allis, Bonfiglio, Büttler, Caron, Ceglarek, Goros, Guan, Huang, Kaabiaa, Kappas, Ke, Magnisali, Peitzsch, Ray, Schioler, Shao, Stanczyk, Taieb, Thomas, Wong, You   +20 more
core   +1 more source

Impact of Heart Failure and Chronic Kidney Disease on All‐Cause Mortality in Patients Undergoing Coronary Angiography: Results From the Finnish Kardio Multicentre Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Heart failure (HF) and chronic kidney disease (CKD) are common comorbidities among patients undergoing coronary angiography. Both conditions are associated with increased risk of adverse cardiovascular outcomes and mortality. However, the joint prognostic impact of HF and CKD in this patient population remains unclear. Aims We aimed
Jari A. Laukkanen, Jaakko Immonen, Jussi Hernesniemi, Mari Merentie, Ashish H. Shah, Markku Eskola, Sudhir Kurl, Setor K. Kunutsor   +7 more
wiley   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

Nature Genetics, 2013
Adrenal aldosterone-producing adenomas (APAs) constitutively produce the salt-retaining hormone aldosterone and are a common cause of severe hypertension. Recurrent mutations in the potassium channel gene KCNJ5 that result in cell depolarization and Ca2+
U. Scholl, Gerald Goh, Gabriel Stölting, R. C. de Oliveira, Murim Choi, J. Overton, Annabelle L. Fonseca, R. Korah, Lee F. Starker, J. Kunstman, M. Prasad, Erum A. Hartung, N. Mauras, M. Benson, T. Brady, J. Shapiro, E. Loring, C. Nelson-Williams, S. Libutti, S. Mane, P. Hellman, G. Westin, G. Åkerström, P. Björklund, T. Carling, C. Fahlke, P. Hidalgo, R. Lifton   +27 more
semanticscholar   +1 more source

The potential of ACTH in the genesis of primary aldosteronism.

Frontiers in Endocrinology, 2016
Aldosterone is a homeostatic hormone, rising in volume depletion, sodium deficiency and potassium loading, in response to angiotensin11 and elevation of plasma potassium.
John Watson Funder, John Watson Funder
doaj   +1 more source

Prevalence and Prognostic Impact of Coronary Chronic Total Occlusions in Patients With Cardiogenic Shock

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Mortality in patients with cardiogenic shock (CS) remains high despite advanced treatment strategies in CS patients, underlining the need for the identification of predictors of prognosis in CS patients. Therefore, the present study investigates the prognostic impact of coronary chronic total occlusions (CTO) in patients with CS ...
Michael Behnes, Moritz Schmidberger, Giuseppe Vadalà, Alice Moroni, Juan‐Luis Guiterrez‐Chico, Stylianos Pyxaras, Alexander Bufe, Florian Krötz, Kambis Mashayekhi, Mohamed Ayoub, Jonas Rusnak, Mohammad Abumayyaleh, Jonas Dudda, Kathrin Weidner, Ibrahim Akin, Tobias Schupp   +15 more
wiley   +1 more source

The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: the multi-ethnic study of atherosclerosis. [PDF]

, 2015
Among obese individuals, increased sympathetic nervous system (SNS) activity results in increased renin and aldosterone production, as well as renal tubular sodium reabsorption.
Allison, MA, Cushman, M, Jenny, NS, McClelland, RL, Rifkin, D   +4 more
core   +3 more sources