Results 11 to 20 of about 4,200 (201)
Antihypertensive therapy with aliskiren [PDF]
Kidney International, 2008 Aliskiren represents the first member in a new class of antihypertensive drugs. Inhibiting the renin–angiotensin system at its rate-limiting step is an idea that has been pursued for >30 years; however, earlier compounds failed because of problems ...
Luft, F.C., Weinberger, M.H.
core +3 more sources
Vascular Health and Risk Management, 2008 Kalathil K SureshkumarDivision of Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, Pennsylvania, USAAbstract: Hypertension is a major risk factor for the development of cardiovascular and renal disease.
Kalathil K Sureshkumar
doaj +1 more source
Drug Design, Development and Therapy, 2015 Jing-Tao Zhang, Ke-Ping Chen, Ting Guan, Shu Zhang Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China ...
Zhang JT, Chen KP, Guan T, Zhang S
doaj +1 more source
Aliskiren administration during early postnatal life sex-specifically alleviates hypertension programmed by maternal high fructose consumption [PDF]
Frontiers in Physiology, 2016 Background: Maternal high fructose (HF) intake induced renal programming and hypertension in male adult offspring. We examined whether maternal HF intake causes programmed hypertension and whether aliskiren administration confers protection against the ...
You-Lin Tain +5 more
doaj +2 more sources
International Journal of Nephrology and Renovascular Disease, 2012 Yoshiyuki Morishita1, Minami Watanabe1, Shiho Hanawa1, Osamu Iimura2, Sadao Tsunematsu3, Kenichi Ishibashi4, Eiji Kusano11Division of Nephrology, Department of Medicine, Jichi Medical University, Tochigi, Japan; 2Kumakura Clinic, Tochigi, Japan; 3Yuki ...
Morishita Y +6 more
doaj +1 more source
Aldosterone Synthase Inhibition in Diabetes and Cardiorenal Metabolic Disease. [PDF]
J DiabetesJournal of Diabetes, Volume 18, Issue 7, July 2026.
Bloomgarden Z.
europepmc +2 more sources
Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure [PDF]
New England Journal of Medicine, 2016 Among patients with chronic heart failure, angiotensin-converting-enzyme (ACE) inhibitors reduce mortality and hospitalization, but the role of a renin inhibitor in such patients is unknown. We compared the ACE inhibitor enalapril with the renin inhibitor aliskiren (to test superiority or at least noninferiority) and with the combination of the two ...
Mcmurray, John J. V +15 more
openaire +11 more sources
Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet-Dependent Thrombin Formation and Release of Profibrotic TGF-β. [PDF]
FASEB JPlatelets interact with extracellular vesicles shed by hepatic stellate cells to activate both cell types. Extracellular vesicles shed by activated hepatic stellate cells contain inactive prorenin. HSC‐EV interact with quiescent platelets to non‐proteolytically activate ligated prorenin.
Chen R +8 more
europepmc +2 more sources
Endothelin Receptor Antagonists in Resistant Hypertension and Proteinuric Kidney Disease: Receptor Strategy and Volume Management. [PDF]
J Clin Hypertens (Greenwich)ABSTRACT This narrative review examines how endothelin receptor antagonists (ERAs) can be used at the intersection of difficult‐to‐control hypertension, chronic kidney disease (CKD), and albuminuria or proteinuria. For clinicians, the central question is not receptor selectivity alone, but whether a specific agent, indication, dose, background therapy,
Goldman CK, Goldman JM.
europepmc +2 more sources