Results 21 to 30 of about 4,200 (201)

Investigation renin inhibitor activity from flavonoids derivates by in silico study

Journal of Advanced Pharmaceutical Technology & Research, 2023
Flavonoids have various pharmacological activities, such as antihypertensive, anticancer, and and antidiabetic effects. Several studies have shown that luteolin, quercetin, kaempferol, myricetin, naringenin, hesperetin, and epicatechin have ...
Aprilita Rina Yanti Eff, Ivana Theresia Yenhart, Yonatan Eden, Sri Teguh Rahayu, Putu Gita Mayawidyaswari Mahayasih   +4 more
doaj   +1 more source

Oral direct renin inhibitor aliskiren reduces in vivo oxidative stress and serum matrix metalloproteinase-2 levels in patients with permanent atrial fibrillation

Journal of Arrhythmia, 2015
We aimed to determine the effects of the oral direct renin inhibitor aliskiren on in vivo oxidative stress in atrial fibrillation (AF) patients. In this study, 150 mg oral direct renin inhibitor aliskiren was administered once daily to 12 permanent AF ...
Yoshizumi Takei, MD, Minoru Ichikawa, MD, PhD, Yoshiyuki Kijima, MD, PhD   +2 more
doaj   +1 more source

Aliskiren reduces albuminuria after kidney transplantation [PDF]

, 2017
Background: The renoprotective effects of agents inhibiting the renin-angiotensin system in renal transplant recipients have been supposed but not finally proven.
Boleslaw Rutkowski, Rutkowski, Przemyslaw, Przemyslaw Rutkowski, Renke, Marcin, Andrzej L. Chamienia, Przybylska, Milena, Biedunkiewicz, Bogdan, Alicja M. Debska-Slizien, Małgorzewicz, Sylwia, Tylicki, Leszek, Slawomir Lizakowski, Marcin Renke, Lizakowski, Slawomir, Rutkowski, Boleslaw, Leszek Tylicki, Sylwia Małgorzewicz, Milena Przybylska, Bogdan Biedunkiewicz, Debska-Slizien, Alicja, Chamienia, Andrzej, Zbigniew Heleniak, Heleniak, Zbigniew   +21 more
core   +1 more source

Aliskiren and valsartan in combination is a promising therapy for hypertensive renal injury in rats

Clinical and Experimental Hypertension, 2018
Neither ACEI nor ARBs completely repress the RAAS. Aliskiren is a newer agent that inhibits renin. However, it increases the biosynthesis and secretion of renin and prorenin, that might induce renal tissue damage.
Hala Salah Abdel Kawy
doaj   +1 more source

Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes.

PLoS ONE, 2010
ObjectivePre-treatment with angiotensin receptor blockers is known to improve neurological outcome after stroke. This study investigated for the first time, whether the renin inhibitor aliskiren has similar neuroprotective effects.MethodsSince aliskiren ...
Kristin Schmerbach, Thiemo Pfab, Yi Zhao, Juraj Culman, Susanne Mueller, Arno Villringer, Dominik N Muller, Berthold Hocher, Thomas Unger, Christa Thoene-Reineke   +9 more
doaj   +1 more source

Angioedemas associated with renin-angiotensin system blocking drugs: Comparative analysis of spontaneous adverse drug reaction reports.

PLoS ONE, 2020
IntroductionAngioedema is a subcutaneous swelling typically affecting the face, larynx or pharynx. It is a known adverse drug reaction (ADR) of ACE inhibitors (ACEi), angiotensin-II-receptor blockers (ARBs) and aliskiren (renin inhibitor).
Diana Dubrall, Matthias Schmid, Julia Carolin Stingl, Bernhardt Sachs   +3 more
doaj   +1 more source

Use of aliskiren in a 'real-life' model of hypertension management: analysis of national Web-based drug-monitoring system in Italy.

, 2012
Introduction In Italy, prescriptions of the direct renin inhibitor aliskiren (aliskiren) to high-risk hypertensive patients must be electronically filled by specialized physicians only when at least two antihypertensive drug classes (independently of the
TOCCI, GIULIANO, VOLPE, Massimo, Marisa De Rosa, Aliskiren Registry Aifa Drug Monitoring Program:, Elisabetta Fedozzi, Massimo Volpe, Francesca Bianchini, Anna Covezzoli, Aldo P. Maggioni, Giuliano Tocci   +9 more
core   +1 more source

Comparative Effect of a Renin Inhibitor and a Thiazide Diuretic on Renal Tissue Oxygenation in Hypertensive Patients

Kidney & Blood Pressure Research, 2015
Background/Aims: The purpose of the present study was to compare the direct renin inhibitor aliskiren to the diuretic hydrochlorothiazide (HCTZ) in their ability to modulate renal tissue oxygenation in hypertensive patients.
Nima Vakilzadeh, Marie-Eve Muller, Valentina Forni, Bastien Milani, Lucie Hoffman, Maciej Piskunowicz, Marc Maillard, Carole Zweiacker, Menno Pruijm, Michel Burnier   +9 more
doaj   +1 more source

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Characteristics and Usefulness of the Direct Renin Inhibitor Aliskiren

Journal of Pharmacological Sciences, 2010
Since renin inhibition interferes with the first and rate-limiting steps in the renin–angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh   +6 more
doaj   +1 more source

Handle Region Peptide Counteracts the Beneficial Effects of the Renin Inhibitor Aliskiren in Spontaneously Hypertensive Rats

, 2011
To investigate whether the putative (pro)renin receptor blocker, the handle region peptide (HRP), exerts effects on top of the blood pressure–lowering and cardioprotective effects of the renin inhibitor aliskiren, spontaneously hypertensive rats were ...
Angelique M. Bouhuizen, A.H. Jan Danser, Ingrid M. Garrelds, Frank Leijten, Richard van Veghel, Joep H.M. van Esch, Van den Berg - Garrelds, Ingrid; id_orcid, Leijten, Frank, Bouhuizen, AM, Danser, Jan, Esch, Joep, van Veghel, Richard   +11 more
core   +2 more sources