Results 21 to 30 of about 2,710 (165)

Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes.

PLoS ONE, 2010
ObjectivePre-treatment with angiotensin receptor blockers is known to improve neurological outcome after stroke. This study investigated for the first time, whether the renin inhibitor aliskiren has similar neuroprotective effects.MethodsSince aliskiren ...
Kristin Schmerbach, Thiemo Pfab, Yi Zhao, Juraj Culman, Susanne Mueller, Arno Villringer, Dominik N Muller, Berthold Hocher, Thomas Unger, Christa Thoene-Reineke   +9 more
doaj   +1 more source

Angioedemas associated with renin-angiotensin system blocking drugs: Comparative analysis of spontaneous adverse drug reaction reports.

PLoS ONE, 2020
IntroductionAngioedema is a subcutaneous swelling typically affecting the face, larynx or pharynx. It is a known adverse drug reaction (ADR) of ACE inhibitors (ACEi), angiotensin-II-receptor blockers (ARBs) and aliskiren (renin inhibitor).
Diana Dubrall, Matthias Schmid, Julia Carolin Stingl, Bernhardt Sachs   +3 more
doaj   +1 more source

Aliskiren administration during early postnatal life sex-specifically alleviates hypertension programmed by maternal high fructose consumption

Frontiers in Physiology, 2016
Background: Maternal high fructose (HF) intake induced renal programming and hypertension in male adult offspring. We examined whether maternal HF intake causes programmed hypertension and whether aliskiren administration confers protection against the ...
You-Lin Tain, Chien-Ning Hsu, Kay Wu, Wei-Chia Lee, Steve Leu, Julie Yu-Hwa Chan   +5 more
doaj   +1 more source

Comparative Effect of a Renin Inhibitor and a Thiazide Diuretic on Renal Tissue Oxygenation in Hypertensive Patients

Kidney & Blood Pressure Research, 2015
Background/Aims: The purpose of the present study was to compare the direct renin inhibitor aliskiren to the diuretic hydrochlorothiazide (HCTZ) in their ability to modulate renal tissue oxygenation in hypertensive patients.
Nima Vakilzadeh, Marie-Eve Muller, Valentina Forni, Bastien Milani, Lucie Hoffman, Maciej Piskunowicz, Marc Maillard, Carole Zweiacker, Menno Pruijm, Michel Burnier   +9 more
doaj   +1 more source

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Characteristics and Usefulness of the Direct Renin Inhibitor Aliskiren

Journal of Pharmacological Sciences, 2010
Since renin inhibition interferes with the first and rate-limiting steps in the renin–angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh   +6 more
doaj   +1 more source

Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2924-2936, August 2026.
Aim A prior non‐randomized study suggests that potassium supplementation may improve survival among furosemide initiators, and a randomized trial suggests that salt substitutes containing potassium might lower stroke risk. We conducted a retrospective cohort study using health‐care data to confirm or refute these associations among new users of ...
Thanh Phuong Pham Nguyen, Sean Hennessy, Colleen M. Brensinger, Warren B. Bilker, Laura M. Dember, Todd A. Miano, Tat‐Thang Vo, Allison W. Willis, Charles E. Leonard   +8 more
wiley   +1 more source

Apiotrichum‐Centered Fungal Interaction Network Disturbance Correlates With Increased Arterial Stiffness

Aging Cell, Volume 25, Issue 8, August 2026.
Apiotrichum‐centered gut fungal network disturbance correlates with increased arterial stiffness. Five driver genera including Apiotrichum, Mycothermus, Flavocillium, Hyaloscypha, and Microscypha regulate the interaction shift. Thirty‐nine metabolites comprising organic acids, fatty acyls, and sucrose target vasoconstriction regulators CYP11B2, ROCK2 ...
Jiarui Chen, Jialin He, Bingqi Ye, Jialu Yang, Ludi Liu, Jingmeng Ju, Sinan Li, Benjie Li, Min Xia, Yan Liu   +9 more
wiley   +1 more source

Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function.

PLoS ONE, 2013
Myocardial fibrosis, a major pathophysiologic substrate of heart failure with preserved ejection fraction (HFPEF), is modulated by multiple pathways including the renin-angiotensin system.
Hui Zhi, Ivan Luptak, Gaurav Alreja, Jianru Shi, Jian Guan, Nicole Metes-Kosik, Jacob Joseph   +6 more
doaj   +1 more source

Effect of add-on direct renin inhibitor aliskiren in patients with non-diabetes related chronic kidney disease

BMC Nephrology, 2012
Background The renin-angiotensin-aldosterone system (RAAS) plays an important role in the progression of chronic kidney disease (CKD). Although dual RAAS inhibition results in worse renal outcomes than monotherapy in high risk type 2 diabetes patients ...
Li Szu-yuan, Chen Yung-Tai, Yang Wu-Chang, Tarng Der-Cherng, Lin Chih-Ching, Yang Chih-Yu, Liu Wen-Sheng   +6 more
doaj   +1 more source

Aliskiren Reduces the Adrenal Zona Glomerulosa Apoptosis and Autophagy in Wistar Rats with 2K1C Hypertension

International Journal of Hypertension, 2020
Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension,
Veronica S. de Matos, Ana L. R. do Nascimento, Priscila G. Pereira, Kíssila Rabelo, Cherley B. V. Andrade, Alan C. N. Moraes, Camila Salata, Victor H. V. de O. Araújo, Bianca Torres Ciambarella, Aline Bonfim Vieira, Luciana Lontro Alves, Jemima F. R. da Silva, Jorge J. de Carvalho   +12 more
doaj   +1 more source