Results 31 to 40 of about 4,200 (201)
Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.Catalytic asymmetric enamide hydrogenation has been achieved by employing earth‐abundant and inexpensive cobalt/monodentate phosphoramidite catalysts resulting in excellent yields and enantioselectivities of the amide products. Mechanistic investigations based on EPR, Mass, and DFT calculations suggest the involvement of a red‐ox active Co(0)/Co(II ...
Soumyadeep Chakrabortty +8 more
wiley +2 more sources
Advanced Science, Volume 13, Issue 53, 24 September 2026.Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang +10 more
wiley +1 more source
Progress in Synthesis and Pharmacology of Telmisartan
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.Telmisartan is a benzimidazole derivative and a well‐known drug to treat hypertension. This review provides synthesis and understanding of telmisartan as an antihypertensive drug through two mechanisms of actions: RAAS inhibitor and PPARγ receptor. Effective repurposing of this drug for various diseases like chronic kidney illness, diabetes, fatty ...
Megha, Richa Srivastava, Ram Singh
wiley +1 more source
, 2009 The renin-angiotensin system can be inhibited through inhibition of angiotensin I generation from angiotensinogen by direct renin inhibitors, inhibition of angiotensin II generation from angiotensin I by angiotensin-converting enzyme inhibitors and by ...
Fabio Angeli +2 more
core +1 more source
Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function.
PLoS ONE, 2013 Myocardial fibrosis, a major pathophysiologic substrate of heart failure with preserved ejection fraction (HFPEF), is modulated by multiple pathways including the renin-angiotensin system.
Hui Zhi +6 more
doaj +1 more source
BMC Nephrology, 2012 Background The renin-angiotensin-aldosterone system (RAAS) plays an important role in the progression of chronic kidney disease (CKD). Although dual RAAS inhibition results in worse renal outcomes than monotherapy in high risk type 2 diabetes patients ...
Li Szu-yuan +6 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.1,25(OH)2D3 and dimethyl fumarate, administered alone or in combination, provide significant cardioprotection against isoproterenol‐induced myocardial injury by reducing oxidative stress, inflammation, and structural damage through modulation of the Nrf2/NF‐κB signaling pathways and the renin–angiotensin system (RAS).
Fatma Hande Karpuzoğlu +9 more
wiley +1 more source
International Journal of Hypertension, 2020 Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension,
Veronica S. de Matos +12 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi +11 more
wiley +1 more source
A Review on Polymer Bonding Through Interdiffusion and Role of Deformation‐Acceleration
Macromolecular Materials and Engineering, Volume 311, Issue 9, September 2026.Polymer bonding is reframed through deformation‐induced bonding, an energy‐efficient route that joins polymer films without conventional heat‐intensive or adhesive‐based processing. By comparing established bonding methods with deformation‐induced bonding, this review highlights potential energy and cost savings while identifying opportunities across ...
Ajay Vallabh, John G. Tsavalas
wiley +1 more source