Results 91 to 100 of about 483,373 (407)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

New Insights on Biological Activities, Chemical Compositions, and Classifications of Marine Actinomycetes Antifouling Agents

Microorganisms, 2023
Biofouling is the assemblage of undesirable biological materials and macro-organisms (barnacles, mussels, etc.) on submerged surfaces, which has unfavorable impacts on the economy and maritime environments.
Radwa N. Morgan, Amer Al Ali, Mohammad Y. Alshahrani, Khaled M. Aboshanab   +3 more
doaj   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Investigation of the Adrenergic and Opioid Binding affinities, Metabolic Stability, Plasma Protein Binding Properties and Functional Effects of Selected Indole-based Kratom Alkaloids.

Journal of Medicinal Chemistry, 2019
Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding and metabolic stability.
Samuel Obeng, Shyam H Kamble, Morgan E. Reeves, Luis F. Restrepo, Avi Patel, M. Behnke, Nelson Jeng Yeou Chear, S. Ramanathan, Abhisheak Sharma, F. León, T. Hiranita, B. Avery, L. McMahon, C. McCurdy   +13 more
semanticscholar   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Inhibitory effect and mechanism of alkaloids derived from Gelsemium elegans Benth on lung cancer

陆军军医大学学报
Objective To determine the anti-lung cancer effect of koumine (KOU) and total alkaloids of Gelsemium elegans Benth (TAG) and investigate the underlying mechanism. Methods After low, medium and high concentrations (100, 150, 200 μg/mL) of KOU were used to
JIN Mingjing, LI Yanping, ZHOU Huansi
doaj   +1 more source

Estudo em raiz e ráquis foliar de spathelia excelsa: fitoquímica e atividade frente ao fungo Moniliophthora perniciosa associado ao cupuaçuzeiro (Theobroma grandiflorum)

Química Nova, 2012
The chemical composition of Spathelia excelsa (Krause) R. S. Cowan & Brizicky was investigated and the limonoids harrisonin (1) and deacetylspathelin (2), alkaloids folinin and casimiroin mixture (3a, b), plus a further casimiroin (3b) were identified in
Loretta Ennes de Carvalho, Maria da Paz Lima, Ariane da Costa Máximo, Elaine Cristina da Silva Pereira, Wagner Alan dos Santos Moreira, Antônio Gilberto Ferreira, Solange de Mello Véras, Maria Geralda de Souza   +7 more
doaj   +1 more source

Exploration of Synergistic Pesticidal Activities, Control Effects and Toxicology Study of a Monoterpene Essential Oil with Two Natural Alkaloids [PDF]

, 2023
Jianwei Xu, Min Lv, Shanshan Fang, Yanyan Wang, Houpeng Wen, Shaoyong Zhang, Hui Xu   +6 more
openalex   +1 more source

In vitro wound healing of tumor cells: inhibition of cell migration by selected cytotoxic alkaloids

BMC Pharmacology and Toxicology, 2019
Cell migration is involved in several pathological processes such as tumor invasion, neoangiogenesis and metastasis. Microtubules are needed in directional migration.
Xiaojuan Wang, C. Decker, L. Zechner, S. Krstin, M. Wink   +4 more
semanticscholar   +1 more source

Specialist or generalist? Feeding ecology of the Malagasy poison frog Mantella aurantiaca [PDF]

, 2007
We studied the diet of a population of free-ranging Mantella aurantiaca, an alkaloid-containing poison frog from Madagascar. As in other poison frogs, this species is thought to sequester alkaloids from arthropod prey.
Fisher, Brian L., Gamboni, Ilona, Griffiths, Richard A., Vences, Miguel, Vieites, David R., Woodhead, Cindy   +5 more
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