Results 1 to 10 of about 123 (108)
Dna, 2023 Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation.
Tatyana Karabencheva-Christova +2 more
exaly +5 more sources
Structure and mechanism of the alkane-oxidizing enzyme AlkB
Nature Communications, 2023 Alkanes are the most energy-rich form of carbon and are widely dispersed in the environment. Their transformation by microbes represents a key step in the global carbon cycle.
Xue Guo +8 more
doaj +4 more sources
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB [PDF]
BMC Genomics, 2003 Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz +3 more
doaj +3 more sources
Sequence Dependent Repair of 1,N6-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB [PDF]
Molecules, 2021 Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair.
Rui Qi +5 more
doaj +4 more sources
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA [PDF]
Nature, 2008 Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation mechanism. ABH2 has the primary role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA), whereas AlkB and ABH3 preferentially repair single-stranded DNA (ssDNA) lesions
Cai-Guang Yang, Xing Jian, Chengqi Yi
exaly +5 more sources
Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage [PDF]
Journal of Biological Chemistry, 2016 The AlkB repair enzymes, including Escherichia coli AlkB and two human homologues, ALKBH2 and ALKBH3, are iron(II)- and 2-oxoglutarate-dependent dioxygenases that efficiently repair N(1)-methyladenine and N(3)-methylcytosine methylated DNA damages. The development of small molecule inhibitors of these enzymes has seen less success.
Qi Li, Cai-Guang Yang, Jianhua Gan
exaly +3 more sources
Copper Inhibits the AlkB Family DNA Repair Enzymes under Wilson’s Disease Condition [PDF]
Chemical Research in Toxicology, 2017 Disturbed metabolism of copper ions can cause diseases such as Wilson's disease (WD). In this work, we investigated the inhibitory effect of Cu(II) ion in vitro on the AlkB family DNA repair enzymes, which are members of the Fe(II)/alpha-ketoglutarate-dependent dioxygenase and include human ALKBH2, ALKBH3, and E. coli AlkB proteins.
Deyu Li, Ke Bian
exaly +3 more sources
Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification [PDF]
Journal of Biological Chemistry, 2012 Humans express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylation damage to nucleobases. The biochemical and physiological roles of these paralogs remain largely uncharacterized, hampering insight into the evolutionary expansion of the AlkB family. However, AlkB homolog 8 (ABH8),
Farhad Forouhar, , Irini Topalidou
exaly +3 more sources
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro [PDF]
Nucleic Acids Research, 2019 5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET) family enzymes, which are α-ketoglutarate (α-KG)/Fe(II)-dependent dioxygenases.
Deyu Li, Ke Bian, Marco Jost
exaly +5 more sources
Arab Journal of Basic and Applied Sciences, 2023 Thirty-four different soil Streptomyces isolates previously recovered from soils of different gas stations that were historically polluted with fuel oil for long time were analyzed for their ability to produce five different hydrolytic enzymes, as well ...
Ismail Saadoun +5 more
doaj +1 more source