Novel enzymes involved in the biotransformation of oxytetracycline by Arthrobacter nicotianae OTC-16 [PDF]
Microbiology SpectrumCurrent research on the microbial degradation of antibiotic residues primarily focuses on isolating degrading bacteria and characterizing their metabolites.
Beibei Wang +5 more
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Molecular dynamic analysis of the functional role of amino acid residues V99, F124 and S125 of human DNA dioxygenase ABH2 [PDF]
Вавиловский журнал генетики и селекцииThe ABH2 enzyme belongs to the AlkB-like family of Fe(II)/α-ketoglutarate-dependent dioxygenases. Various non-heme dioxygenases act on a wide range of substrates and have a complex catalytic mechanism involving α-ketoglutarate and an Fe(II) ion as a ...
M. Zhao +3 more
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Genome mining and screening for plastic-degrading potential in marine bacteria [PDF]
Applied Microbiology and BiotechnologyMarine plastic litter, including microplastics, has a profound impact on the ocean and its wildlife, and strategies to remove/eliminate it are needed. Microbial biodegradation, particularly by bacteria, offers a potential solution, where a link between ...
Rafaela Perdigão +5 more
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Microorganisms from Antarctica: A Review of Their Potential in the Bioremediation of Hydrocarbon-Contaminated Soils [PDF]
MicroorganismsAntarctica’s extreme cryospheric conditions impose severe thermodynamic constraints on the natural attenuation of hydrocarbon pollutants. Despite the Antarctic Treaty System’s protections, the footprint of human logistics has left persistent reservoirs ...
Jaime Naranjo-Moran +2 more
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Identification and characterization of two novel Acinetobacter species capable of degrading polyester [PDF]
Microbiology SpectrumThe ubiquitous presence of Acinetobacter species in the environment holds significant biotechnology potential, particularly in the degradation of various pollutants. In this study, we characterize two plastic-degrading bacteria, strains CAAS 2-6 and CAAS
Mengli Xia +6 more
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Catalytic Mechanism of the Bacterial Non-Heme Fe(II) and 2-Oxoglutarate Dependent Enzyme AlkB with Single-Stranded DNA Containing Complex Guanine Adducts [PDF]
Inorganic ChemistryThe bacterial nonheme Fe(II)/2-oxoglutarate (2OG)-dependent enzyme AlkB repairs alkylation damages in single-stranded DNA (ss-DNA) nucleotide bases. This study examines for the first time the reaction mechanism of the AlkB-catalyzed repair of alkylated and exocyclic guanine adducts (GAs) in single-stranded DNA induced by everyday chemical exposures ...
Sreerag Melayikandy +8 more
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Can flavoprotein monooxygenases functionalize long-chain n-alkanes? [PDF]
PLoS ONELong-chain n-alkane functionalization is relevant for industrial and environmental applications, but it remains a significant challenge due to the inherent stability of their covalent bonds. Biocatalytic approaches offer promising strategies due to their
Raul Mireles +3 more
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Oxidative intermediates captured during demethylation of DNA and RNA [PDF]
E3S Web of Conferences, 2021 DNA and RNA have various methylation modifications or damage that are directly related to some human diseases and physiological regulation. Most of these methylation modifications are reversible and can be dynamically repaired by RNA or DNA demethylases.
Wang Ying, Zhang Jianyu
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The role of demethylase AlkB homologs in cancer
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
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An Overview of the Electron-Transfer Proteins That Activate Alkane Monooxygenase (AlkB)
Frontiers in Microbiology, 2022 Alkane-oxidizing enzymes play an important role in the global carbon cycle. Alkane monooxygenase (AlkB) oxidizes most of the medium-chain length alkanes in the environment. The first AlkB identified was from P.
Shoshana C. Williams +1 more
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