Results 51 to 60 of about 128 (100)

Horizontal Gene Transfer and Genome Rearrangements Shape Bacterial Adaptation for Bioremediation

Environmental Microbiology, Volume 28, Issue 7, July 2026.
Exposure to xenobiotics triggers genome evolution and horizontal gene transfer (HGT), driving the acquisition of novel catabolic functions. These genomic adaptations provide a competitive fitness advantage that reshapes microbial community structure and enhances biodegradation impact.
Zaki Saati‐Santamaría, Amando Flores, Inés Canosa, Paula García‐Fraile   +3 more
wiley   +1 more source

A Virus in American Blackcurrant (Ribes americanum) with Distinct Genome Features Reshapes Classification in the Tymovirales

Viruses, 2018
A novel virus with distinct genome features was discovered by high throughput sequencing in a symptomatic blackcurrant plant. The virus, tentatively named Ribes americanum virus A (RAVA), has distinct genome organization and molecular features bridging ...
Thanuja Thekke-Veetil, Thien Ho, Joseph D. Postman, Robert R. Martin, Ioannis E. Tzanetakis   +4 more
doaj   +1 more source

Methyltransferase‐Like 14 Promotes the Angiogenesis of Hepatocellular Carcinoma via Targeting Vascular Endothelial Growth Factor A

Cancer Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background N6‐methyladenosine (m6A) modification is a pivotal epitranscriptomic regulator implicated in tumor progression. As a core component of the m6A methyltransferase complex, METTL14 is known to suppress tumorigenesis; however, its specific role in tumor angiogenesis remains elusive. Given that Vascular Endothelial Growth Factor A (VEGFA)
Xinmiao Xiong, Chuanfang Shu, Ziqun Qu, Jiayan Li, Wei Ye, Lili Wang   +5 more
wiley   +1 more source

A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic N ⁶ -methyladenine (6mA)

Proceedings of the National Academy of Sciences
DNA N 6 -methyladenine (6mA) is a newly recognized transcription-associated epigenetic mark in eukaryotes. While its methylation pathway has been well established, the identity of eukaryotic 6mA demethylase(s) responsible for its removal and dynamic regulation has remained elusive.
Junhua Niu, Haoze Yu, Yongqiang Liu, Lanheng Nie, Bei Nan, Wenxin Zhang, Ni Song, Shaoqin Rong, Dan Zhou, Shan Gao   +9 more
openaire   +3 more sources

Genome‐wide identification of MsAlkB family genes and functional analysis of MsALKBH2 as an RNA m6A eraser in alfalfa (Medicago sativa L.) subject to drought stress

Grassland Research
Background N6‐methyladenosine (m6A), the most prevalent mRNA modification in plants, plays a pivotal role in developmental processes and stress responses.
Xianglong Zhao, Jie Zhao, Hui Zhang, Yan Li, Chao Sui, Wengang Xie, Zhipeng Liu, Mingjia Chen, Wenxian Liu   +8 more
doaj   +1 more source

Molecular dynamic analysis of the functional role of amino acid residues V99, F124 and S125 of human DNA dioxygenase ABH2

Вавиловский журнал генетики и селекции
The ABH2 enzyme belongs to the AlkB-like family of Fe(II)/α-ketoglutarate-dependent dioxygenases. Various non-heme dioxygenases act on a wide range of substrates and have a complex catalytic mechanism involving α-ketoglutarate and an Fe(II) ion as a ...
M. Zhao, T. E. Tyugashev, A. T. Davletgildeeva, N. A. Kuznetsov   +3 more
doaj   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.

PLoS ONE, 2014
The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno adducts on the nucleobases ...
Daria Zdżalik, Cathrine B Vågbø, Finn Kirpekar, Erna Davydova, Alicja Puścian, Agnieszka M Maciejewska, Hans E Krokan, Arne Klungland, Barbara Tudek, Erwin van den Born, Pål Ø Falnes   +10 more
doaj   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, Volume 4, Issue 2, Page 91-107, June 2026.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source