Results 71 to 80 of about 128 (100)

Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy

Cell Death and Disease
Diabetic cardiomyopathy (DCM) is a prevalent myocardial microvascular complication of the myocardium with a complex pathogenesis. Investigating the pathogenesis of DCM can significantly contribute to enhancing its prevention and treatment strategies. Our
Juan Zhen, Xia Sheng, Tianlong Chen, Haitao Yu   +3 more
doaj   +1 more source

ALKBH1L Is an m⁶A Demethylase and Mediates PVY Infection in Nicotiana benthamiana Through m⁶A Modification

Plants
N6-methyladenosine (m6A), the most prevalent internal mRNA modification in eukaryotes, is also present in plants and is known to influence plant–virus interactions.
Jue Zhou, Shuocong Sun, Jingtao Yuan, Li Dong, Xinhua Wang, Chenchen Jing, Muhammad Amjad Nawaz, Ruimin Tang, Hui Cao, Bihua Nie, Xue Feng   +10 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Sal) is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, an environmental toxin that causes Parkinson ...
Jianan Wang, Yuanyuan Ran, Zihan Li, Tianyuan Zhao, Fangfang Zhang, Juan Wang, Zongjian Liu, Xuechai Chen   +7 more
doaj   +1 more source

N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication

Viruses
Enteroviruses such as coxsackievirus B3 are identified as a common cause of viral myocarditis, but the potential mechanism of its replication and pathogenesis are largely unknown.
Hainian Zhao, Zhiyun Gao, Jiawen Sun, Hongxiu Qiao, Yan Zhao, Yan Cui, Baoxin Zhao, Weijie Wang, Sandra Chiu, Xia Chuai   +9 more
doaj   +1 more source

The role of the ALKBH5 RNA demethylase in invasive breast cancer

Discover Oncology
Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase.
Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan   +15 more
doaj   +1 more source

pH Tunes the DNA Repair Efficiency and Strand Preference of the AlkB Family Enzymes

Chemical Research in Toxicology
Samuel D. Howarth, Quentin J. Mylie, Evans Boateng-Boakye, Vincent Falkowski, Ambar Oliver Mella, Rafael Fermin, Zhiyuan Peng, Xin Bush, Yi-Tzai Chen, Jian Ma, Bongsup Cho, Deyu Li   +11 more
openaire   +1 more source

Genome-wide identification of AlkB homologous gene family and its expression patterns in rice under drought stress

Plant Growth Regulation
Xiaoguang Chen, Yue Zhang, Zichan Ye, Jinxi Xiang, Shihuan He, Yunxia Fang, Xiaoqin Zhang, Dawei Xue   +7 more
openaire   +1 more source

Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases

DNA Repair, 2020
Iron-dependent dioxygenases of the AlkB protein family found in most organisms throughout the tree of life play a major role in oxidative dealkylation processes. Many of these enzymes have attracted the attention of researchers across different fields and have been subjected to thorough biochemical characterization because of their link to human health
Johan Robben, Vincent Van Deuren, Sander Plessers   +2 more
exaly   +4 more sources

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An alkane monooxygenase (AlkB) family in which all electron transfer partners are covalently bound to the oxygen-activating hydroxylase

Journal of Inorganic Biochemistry, 2022
Alkane monooxygenase (AlkB) is a non-heme diiron enzyme that catalyzes the hydroxylation of alkanes. It is commonly found in alkanotrophic organisms that can live on alkanes as their sole source of carbon and energy. Activation of AlkB occurs via two-electron reduction of its diferric active site, which facilitates the binding, activation, and cleavage
Rachel Narehood Austin, Christina Vizcarra   +1 more
exaly   +3 more sources