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Copper Inhibits the AlkB Family DNA Repair Enzymes under Wilson’s Disease Condition [PDF]
Chemical Research in Toxicology, 2017 Disturbed metabolism of copper ions can cause diseases such as Wilson's disease (WD). In this work, we investigated the inhibitory effect of Cu(II) ion in vitro on the AlkB family DNA repair enzymes, which are members of the Fe(II)/alpha-ketoglutarate-dependent dioxygenase and include human ALKBH2, ALKBH3, and E. coli AlkB proteins.
Deyu Li, Ke Bian
exaly +3 more sources
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Current Stem Cell Research and Therapy, 2018
The study of epigenetic regulation has made substantial progress in recent years. The AlkB family in E. coli was identified as a type of DNA repair enzyme that removes alkyl adducts from nucleobases. Recently, nine mammalian homologs, ALKBH1-9, have been successfully identified and defined as diverse demethylases.
Liang Xie, Quan Yuan, Yuting Liu
exaly +3 more sources
The study of epigenetic regulation has made substantial progress in recent years. The AlkB family in E. coli was identified as a type of DNA repair enzyme that removes alkyl adducts from nucleobases. Recently, nine mammalian homologs, ALKBH1-9, have been successfully identified and defined as diverse demethylases.
Liang Xie, Quan Yuan, Yuting Liu
exaly +3 more sources
Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases
Biochemistry, 2019The α-ketoglutarate-dependent (AlkB) superfamily of FeII/2-oxoglutarate (2-OG)-dependent dioxygenases consists of a unique class of nucleic acid repair enzymes that reversibly remove alkyl substituents from nucleobases through oxidative dealkylation.
Li-Jun Xie, Li Liu, Liang Cheng
openaire +2 more sources
International Journal of Molecular SciencesN6-methyladenosine (m6A) is an abundant and pervasive post-transcriptional modification in eukaryotic mRNAs. AlkB homolog (ALKBH) proteins play crucial roles in RNA metabolism and translation, participating in m6A methylation modification to regulate plant development.
Hongju Jian, Jian Hongju
exaly +3 more sources
International Journal of Molecular SciencesAlkane-oxidizing bacteria play a crucial role in the global carbon cycle. Rhodococcus species are well-known hydrocarbon degraders, distinguished by the harboring of multiple homologs of AlkB family alkane monooxygenases. Although different types of rhodococcal AlkBs have been described, the overall picture of their diversity remains unclear, leaving ...
Irina Pozdnyakova-Filatova +2 more
exaly +3 more sources
Angewandte Chemie, 2014
AbstractThe AlkB family demethylases AlkB, FTO, and ALKBH5 recognize differentially methylated RNA/DNA substrates, which results in their distinct biological roles. Here we identify key active‐site residues that contribute to their substrate specificity.
Chenxu, Zhu, Chengqi, Yi
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AbstractThe AlkB family demethylases AlkB, FTO, and ALKBH5 recognize differentially methylated RNA/DNA substrates, which results in their distinct biological roles. Here we identify key active‐site residues that contribute to their substrate specificity.
Chenxu, Zhu, Chengqi, Yi
openaire +2 more sources
Journal of Computational Chemistry, 2013
To facilitate computational study of proteins in the AlkB family and related α‐ketoglutarate/Fe(II)‐dependent dioxygenases, we have tested a simple modeling strategy for the non‐heme Fe(II) site in which the iron is represented by a simple +2 point charge with Lennard‐Jones parameters.
Xueqin Pang, Ke-Li Han, Qiang Cui 0003
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To facilitate computational study of proteins in the AlkB family and related α‐ketoglutarate/Fe(II)‐dependent dioxygenases, we have tested a simple modeling strategy for the non‐heme Fe(II) site in which the iron is represented by a simple +2 point charge with Lennard‐Jones parameters.
Xueqin Pang, Ke-Li Han, Qiang Cui 0003
openaire +2 more sources
International Journal of Biological Macromolecules
N6-methyladenosine (m6A) is the most abundant chemical modification on eukaryotic mRNAs. In crustaceans, the absence of canonical m6A demethylases, namely fat mass and obesity-associated protein (FTO) and AlkB Homolog 5 (ALKBH5), poses an unresolved puzzle about the m6A demethylation machinery of these invertebrates.
Yiguo, Lei +5 more
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N6-methyladenosine (m6A) is the most abundant chemical modification on eukaryotic mRNAs. In crustaceans, the absence of canonical m6A demethylases, namely fat mass and obesity-associated protein (FTO) and AlkB Homolog 5 (ALKBH5), poses an unresolved puzzle about the m6A demethylation machinery of these invertebrates.
Yiguo, Lei +5 more
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pH effects on oxidative modification of alkylative DNA adducts by the AlkB-family enzymes
2021Yitzai Chen +5 more
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