Results 61 to 70 of about 128 (100)

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: ALKBH1, an AlkB homologue in the 2-oxoglutarate and Fe2+ dependent hydroxylase family, is a histone dioxygenase that removes methyl groups from histone H2A. Studies of transgenic mice lacking Alkbh1 reveal that most Alkbh1-/- embryos die
Rune Ougland, Ida Jonson, Marivi Nabong Moen, Gaute Nesse, Gry Asker, Arne Klungland, Elisabeth Larsen   +6 more
doaj   +1 more source

Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation

Frontiers in Pharmacology, 2020
Purpose:N6-methyladenosine (m6A) mRNA methylation is affected by dietary factors and associated with lipid metabolism; however, whether the regulatory role of resveratrol in lipid metabolism is involved in m6A mRNA methylation remains unknown.
Jiamin Wu, Yi Li, Jiayao Yu, Zhending Gan, Wenyao Wei, Chao Wang, Lili Zhang, Tian Wang, Xiang Zhong   +8 more
doaj   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates n‐alkane degradation in Pseudomonas aeruginosa SJTD‐1

mLife
Transmembrane alkane monooxygenase (AlkB)‐type monooxygenases, especially AlkB2 monooxygenases, are crucial for aerobic degradation of the medium‐to‐long‐chain n‐alkanes in hydrocarbon‐utilizing microorganisms.
Wanli Peng, Xiuli Wang, Qinchen Liu, Zhihong Xiao, Fulin Li, Nannan Ji, Zhuo Chen, Jiaying He, Junhao Wang, Zixin Deng, Shuangjun Lin, Rubing Liang   +11 more
doaj   +1 more source

A New Phylogenetic Approach to Classification of AlkB Family Alkane Monooxygenases from Rhodococcus (Sensu Lato) Group Reveals Huge Diversity and Allows to Propose Generalized AlkB Types

The elimination of hydrocarbon pollution is a critical environmental challenge, often addressed using biotechnological approaches. The study of alkane oxidizing bacteria is an important task, as it will allow developing new approaches to oil pollution treatment and improving existing ones.
Kirill V. Petrikov, Anna A. Vetrova, Anastasia A. Ivanova, Olesya I. Sazonova, Irina Yu Pozdnyakova-Filatova   +4 more
openaire   +1 more source

ALKBH1 activity in vitro and human cell lines by isotope dilution mass spectrometry.

PLoS ONE
AlkB homolog 1 (ALKBH1) is a member of the AlkB family of Fe(II) and α-ketoglutarate (α-KG)-dependent dioxygenases, known for its enzymatic activity on various nucleic acid substrates.
Bennett Henzeler, Olga Hofmeister, Ken Kögel, Yuyang Qi, Felix Hagelskamp, Matthias Heiß, Florian Schelter, Felix Xu, Lena J Daumann, Thomas Carell, Stefanie Kaiser, Sabine Schneider   +11 more
doaj   +1 more source

A new target: AlkBH2 promotes bladder cancer by upregulation of inflammation.

PLoS ONE
A close relationship exists between inflammation and cancer. Recent studies have highlighted inflammation as a significant contributor to the progression of bladder cancer.
Zhangjie Yang, Jinhu Ma, Ziyang Qiang, Wenhao Xie, Liang Jiao, Guojun Chen   +5 more
doaj   +1 more source

CrgA Protein Represses AlkB2 Monooxygenase and Regulates the Degradation of Medium-to-Long-Chain n-Alkanes in Pseudomonas aeruginosa SJTD-1

Frontiers in Microbiology, 2019
AlkB monooxygenases in bacteria are responsible for the hydroxylation of medium- and long-chain n-alkanes. In this study, one CrgA protein of Pseudomonas aeruginosa SJTD-1, a member of LysR family, was proved to regulate AlkB2 monooxygenase and the ...
Nannan Ji, Xiuli Wang, Chong Yin, Wanli Peng, Rubing Liang   +4 more
doaj   +1 more source

The emerging role of m6A methylation in prostate-related diseases: mechanisms and clinical implications

Frontiers in Immunology
Prostate-related diseases, including prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa), represent significant threats to the health of the aging male population worldwide.
Qinghua Xie, Hongyan Zhao, Xuan Yang, Hongqi Zhang, Hong Liu, Jinghua Pan, Yan Li, Danping Fan, Xinrong Fan   +8 more
doaj   +1 more source