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Ketone α-alkylation at the more-hindered site
Nature Communications, 2023 Control of the regioselectivity of α-alkylation of carbonyl compounds is a longstanding topic of research in organic chemistry. By using stoichiometric bulky strong bases and carefully adjusting the reaction conditions, selective alkylation of ...
Ming-Ming Li +6 more
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Versatile cell-based assay for measuring DNA alkylation damage and its repair
Scientific Reports, 2021 DNA alkylation damage induced by environmental carcinogens, chemotherapy drugs, or endogenous metabolites plays a central role in mutagenesis, carcinogenesis, and cancer therapy.
Yong Li +5 more
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Green Energy & Environment, 2022 Side-chain alkylation of toluene with methanol is a green pathway to realize the one-step production of styrene under mild conditions, but the low selectivity of styrene is difficult to be improved with by-products of ethylbenzene and xylene.
Zhe Hong +4 more
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Nature Communications, 2023 C−C bond forming reaction by alkylation of aryl rings is a main pillar of chemistry in the production of broad portfolios of chemical products. The dominant mechanism proceeds via electrophilic substitution of secondary and tertiary carbocations over ...
Xinze Du +3 more
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Heterocyclic Communications, 2021 This mini-review encapsulates the latest findings (past 10 years) in the field of the deep eutectic solvents (DESs) application in the alkylation/arylation of different heterocyclic compounds.
Molnar Maja +4 more
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Copper(I)-catalyzed asymmetric alkylation of α-imino-esters
Nature Communications, 2023 Asymmetric alkylation of enolates is one of the most direct and important reactions to prepare α-chiral carbonyl compounds. Except for the classical methods that rely on the use of chiral auxiliaries, asymmetric catalysis emerged as a powerful tool ...
Zong-Ci Liu +3 more
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Kinetic modeling of liquid phase catalytic alkylation of guaiacol with cyclohexene
Chemical Engineering Journal Advances, 2021 The kinetics of the liquid-phase alkylation of guaiacol (G) with cyclohexene (CH) over Amberlyst 36 resin was studied using Langmuir–Hinshelwood–Hougen–Watson (LHHW) heterogeneous kinetic models.
Mardelly Kateryne Montañez-Valencia +3 more
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Regioselective Reactions of Highly Substituted Arynes [PDF]
, 2010 The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported.
Bugga, Pradeep +4 more
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DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s-phase alkylation damage response in S. pombe [PDF]
, 2012 Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching ...
Jacob Z. Dalgaard +5 more
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Synthesis and structures of O-anthrylmethyl-substituted hexahomotrioxacalix[3]arenes [PDF]
, 2016 O-Alkylation of 7,15,23-tri-tert-butyl-25,26,27-trihydroxy-2,3,10,11,18,19-hexahomo-3,11,19-trioxacalix[3]arene (1H₃) with 9-chloromethylanthracene 5 was carried out under different reaction conditions.
Ikejiri, Yusuke +5 more
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