Results 101 to 110 of about 191,241 (287)
SP1‐Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
Advanced Science, EarlyView.Laser capture microdissection‐based proteomics of pancreatic intraepithelial neoplasia (PanIN) identifies specificity protein 1 (SP1) as a key driver of tumorigenesis and progression in pancreatic cancer through glycolytic remodeling. SP1 enhances aerobic glycolysis by transcriptionally activating 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ...
Hexing Hang +21 more
wiley +1 more source
Flexible synthesis of polyfunctionalised 3-fluoropyrroles [PDF]
, 2016 An efficient and selective approach for the synthesis of polyfunctionalised 3-fluoropyrroles has been developed starting from commercial aldehydes.
Cogswell, Thomas J. +2 more
core +1 more source
Advanced Science, EarlyView.A well‐designed experimental model reveals a trade‐off between intrinsic activity and catalytic site density in performance optimization, due to inherent diffusion resistance arising from substrate adsorption at catalytic sites. Abstract Enhancing intrinsic activity and increasing catalytic site density are two widely employed strategies to improve ...
Guo‐Ying Han +13 more
wiley +1 more source
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, EarlyView.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Orbital: The Electronic Journal of Chemistry, 2010 Selectivity of alkylation at the N1 position in pyrimidines (thymine and uracil) was achieved by the application of N3-benzoyl thymine and N3-benzoyl uracil as substrates, where the N3 atom was temporarily protected, exposing the N1 atom as the ...
Fábio D. P. Soares +3 more
doaj
Transmission Infrared Spectra of CH_3-, CD_3-, and C_(10)H_(21)-Ge(111) Surfaces [PDF]
, 2011 The surface chemistry of CH_3–, CD_3–, and C_(10)H_(21)–Ge(111) surfaces prepared through a bromination/alkylation method have been investigated by infrared spectroscopy. Well-ordered CH_3–Ge(111) surfaces could be prepared only if, prior to bromination,
Brunschwig, Bruce S. +2 more
core +1 more source
Advanced Science, EarlyView.A highly efficient method for Pd(II)–NHC (NHC = N‐heterocyclic carbene)‐catalyzed alkylation of primary amides using alkyl organozinc reagents is reported. The sterically‐hindered and readily accessible IPr* is found to be privileged for facilitating this highly challenging alkylation. Comparative studies, application to the synthesis of pharmaceutical
Peng Lei +8 more
wiley +1 more source