Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach
Biotechnology Progress, EarlyView.Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya +7 more
wiley +1 more source
Recyclable Mn<sub>2</sub>O<sub>3</sub>@SiO<sub>2</sub> Nanocatalyst for Selective Mono-N-alkylation of Amines Utilizing a Borrowing-Hydrogen Approach. [PDF]
ACS OmegaSwaathy R, Karthikeyan S.
europepmc +1 more source
ChemistryEurope, EarlyView.A one‐pot protocol to synthesize reactive benzyl‐ and allyl‐halide‐substituted (dihydro)naphthalenes from 2,3‐aryl‐1,3‐butadiene substrates and halogenated alkanes has been developed, using [Cp*RuCl(PPh3)2] as the catalyst. Mechanistic studies revealed an atom transfer radical addition and radical benzannulation sequence, followed by HCl elimination ...
Nicole S. van Leeuwen +9 more
wiley +1 more source
Recent Progress on the <i>O</i>‑Alkylation Reaction of Dialkyl Carbonates with Aromatic Phenolic Compounds. [PDF]
ACS OmegaZhao J, Zhao Y, Yan C, Meng D, Qin L.
europepmc +1 more source
The Challenging P‐Alkylation of Aromatic Phosphorus Heterocycles and Follow‐Up Reactions
ChemistryEurope, EarlyView.P‐alkylation of λ3σ2‐phosphinines is hindered by weak nucleophilicity and scarce synthetic access, previously requiring multistep routes or extreme electrophiles. A direct ambient‐condition method is reported using 3,5‐bis(trimethylsilyl)‐phosphinine/B(C6F5)3 with esters or iso(thio)cyanates to generate stable 1‐R‐phosphininium salts.
Samantha Frank +6 more
wiley +1 more source
Synthesis of an Enzyme‐Triggered Chitosan‐Based Drug Delivery System for Peri‐Implantitis Prevention
Chemistry – A European Journal, EarlyView.ABSTRACT Dental implants have become a leading solution for tooth loss, yet bacterial infections remain a major complication. Antibacterial implant coatings are an important approach to reduce or prevent bacterial infections at the implant. Given the oral cavity's complex microbiome and the importance of some commensal bacteria, it is crucial to ...
Nelly Senze Nnane +7 more
wiley +1 more source
Site-specific ribozyme-mediated alkylation of DNA substrates. [PDF]
Nucleic Acids ResHe Y +7 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley +1 more source
Dual Chemical Looping/Catalytic Process for Alkylation of Benzene With Ethane and Propane Yielding Ethylbenzene and Cumene Over Copper-Containing Mordenite. [PDF]
Angew Chem Int Ed EnglDubray FJ +7 more
europepmc +1 more source