Internal alkyne regio- and chemoselectivity using a zwitterionic [(NHC)Au(I)] catalyst in a silver-free alkyne hydration reaction [PDF]
, 2016 An alkyne hydration of terminal and internal alkynes is reported using a zwitterionic NHC Au catalyst, (BNHC)Au(SMe2) (1), in the absence of silver and Brønsted acid additives.
Chen, Danmin +6 more
core +1 more source
Zirconoarylation of alkynes through p-chloranil-promoted reductive elimination of arylzirconates
Beilstein Journal of Organic Chemistry, 2014 A novel method for the zirconoarylation of alkynes was developed. TCQ-promoted reductive elimination of arylzirconate [LiCp2ZrAr(RC≡CR)], which was prepared by the reaction of zirconocene–alkyne complexes with aryllithium compounds, afforded ...
Xiaoyu Yan, Chao Chen, Chanjuan Xi
doaj +1 more source
Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions
Molecules, 2016 This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
Xiaoguang Zhang, Peiye Liu, Lei Zhu
doaj +1 more source
Insight into Stable, Concentrated Radicals: from Sulfur-functionalized Alkyne-rich Crystalline Frameworks to Simple Alkyne Motifs [PDF]
Organic radicals feature versatile unpaired electrons key for photoelectronic and biomedical applications, but remain difficult to access in stable concentrated forms.
Jun, He +6 more
core +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Orthogonal modification of polymer chain-ends via sequential nitrile oxide–alkyne and azide–alkyne Huisgen cycloadditions [PDF]
, 2011 The α- and ω-chain-ends of well-defined polystyrene chains were functionalized using consecutive Huisgen cycloadditions. Firstly, an α-alkyne, ω-azido heterotelechelic polystyrene precursor was synthesized in three steps: (i) atom transfer radical ...
Lutz, Jean-François +3 more
core +3 more sources
Unveiling the alkyne-π interaction using metal-organic cage compounds
Communications ChemistryAlkynes play a crucial role in chemical synthesis, bio-imaging, and drug design. Despite their significance, the intermolecular interactions involving alkynes have been largely unexplored.
Junrui Liu +10 more
doaj +1 more source
Molecules, 2018 Regioselective anti-allylindation of alkynes was achieved using InBr3 and allylic silanes. Various types of alkynes and allylic silanes were applicable to the present allylindation.
Yoshihiro Nishimoto +4 more
doaj +1 more source
Decarboxylative Hydroalkylation of Alkynes [PDF]
Journal of the American Chemical Society, 2018 The merger of open- and closed-shell elementary organometallic steps has enabled the selective intermolecular addition of nucleophilic radicals to unactivated alkynes. A range of carboxylic acids can be subjected to a CO2 extrusion, nickel capture, migratory insertion sequence with terminal and internal alkynes to generate stereodefined functionalized ...
Nicholas A. Till +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source