Results 61 to 70 of about 37,121 (253)

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Alkyne hydroarylation with Au N-heterocyclic carbene catalysts

Beilstein Journal of Organic Chemistry, 2013
Mono- and dinuclear gold complexes with N-heterocyclic carbene (NHC) ligands have been employed as catalysts in the intermolecular hydroarylation of alkynes with simple unfunctionalised arenes.
Cristina Tubaro, Marco Baron, Andrea Biffis, Marino Basato   +3 more
doaj   +1 more source

Cobalt/Photoredox Catalyzed Desymmetrization of Oxo and Azabicycles via Asymmetric Reductive Coupling With Alkynes

Advanced Science, EarlyView.
A one‐step, asymmetric reductive coupling of alkynes and oxa‐ and aza‐bicyclic olefins using a cobalt/photoredox catalytic system through desymmetrization. ABSTRACT Bicyclo[2.2.1]heptane frameworks represent a privileged structural motif prevalent in numerous natural products and bioactive molecules.
Subhankar Pradhan, Arko Saha, Bholanath Maity, Sayan Dutta, Luigi Cavallo, Basker Sundararaju   +5 more
wiley   +1 more source

Ambient gold-catalyzed O-vinylation of cyclic 1,3-diketone: A vinyl ether synthesis

Beilstein Journal of Organic Chemistry, 2013
Gold-catalyzed O-vinylation of cyclic 1,3-diketones has been achieved for the first time, which provides direct access to various vinyl ethers.
Yumeng Xi, Boliang Dong, Xiaodong Shi
doaj   +1 more source

alkynes

, 2008
Citation: 'alkynes' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.A00236 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial usage
openaire   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Electronic interactions in [Ru3(m3-R2 CCC6H4-4-R1)(m -dppm)(m-CO) (CO)7] (R1 = NO2 and R2 = Fc; R1 = NO2, CN and R2 = Ph)

Journal of the Brazilian Chemical Society, 2003
The co-ordination of FcCCC6H4-4-NO2 (1) to a ruthenium carbonyl cluster to yield [Ru3(mu 3-FcCCC6H4-4-NO2) (mu-dppm)( mu-CO)(CO)7] (2) is reported. The cyclic voltammograms of these compounds and of the analogous clusters [Ru3(mu3 -eta2-C6 H5CCC6H4-4-R ...
Rosseto Renato, Torres José C., Stein Edison, Vargas Maria D.   +3 more
doaj  

A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins[S]

Journal of Lipid Research, 2016
The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be detected upon click reaction with an azide-coupled reporter. Fluorescent
Anne Gaebler, Anke Penno, Lars Kuerschner, Christoph Thiele   +3 more
doaj   +1 more source

Mixed‐Coordination Electrolytes With Molecular Additives for Robust Interphases in High‐Voltage Rechargeable Magnesium Batteries

Advanced Science, EarlyView.
A mixed‐coordination electrolyte (MCE) combined with a molecular additive (MCE‐MA) promotes pseudo ion pair (pIP) formation within a solvent‐separated ion pair (SSIP)–rich environment, enabling a robust interphase that significantly improves the cycle performance of high‐voltage rechargeable magnesium batteries (RMBs).
Dedy Setiawan, Toshihiko Mandai
wiley   +1 more source